Effect of Dantrolene Sodium on Calcium-Overloaded Heart
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概要
- 論文の詳細を見る
Spontaneous asynchronous contractile activity caused by spontaneous release of calcium ions (Ca^<2+>) from the sarcoplasmic reticulum (SR) is thought to be the cause of deterioration of ventricular function under conditions of calcium overload. We examined whether dantrolene sodium, which can inhibit Ca^<2+> release from the skeletal SR, improves the systolic and diastolic function of calcium-overloaded hearts. In isolated hamster left ventricles, the concentration of Ca^<2+> in the perfusate ([Ca^<2+>]_o) was increased from 1 mmol/L to 7 mmol/L in 1-mmol/L steps in the absence (control, n=6) and presence of dantrolene sodium (11.8μmol/L, n=5). Left ventricular developed pressure and its maximum rate of rise (max dP/dt) increased with an increase in [Ca^<2+>]_o up to 4 mmol/L, and decreased with a further increase in [Ca^<2+>]_o. In the presence of dantrolene sodium, developed pressure and max dP/dt increased up to 5 mmol/L [Ca^<2+>]_o. Thus, dantrolene sodium improves Ca^<2+> tolerance. In isolated ventricles perfused with 1 mmol/L [Ca^<2+>]_o, dantrolene sodium decreased developed pressure by 33.7±7.4% and max dP/dt by 37.4±5.6% (mean±SEM, n=8) at 1 mmol/L [Ca^<2+>]_o. In contrast, at 5 mmol/L [Ca^<2+>]_o ('calcium-overloaded state'), dantrolene sodium increased developed pressure by 6.8±2.6% and max dP/dt by 14.4±5.7%, and decreased the end-diastolic pressure by 5.3±1.9% (n=8). Dantrolene sodium partially suppressed the spontaneous contractile activities observed microscopically on the epicardium of ventricles perfused with 5 mmol/L [Ca^<2+>]_o. Dantrolene sodium improved the Ca^<2+> tolerance of left ventricles and exerted positive inotropic effects and decreased diastolic stiffness in calcium-overloaded hamster left ventricles by suppressing spontaneous contractile activity.
- 社団法人日本循環器学会の論文
- 1997-09-20
著者
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Ishide Nobumasa
First Department of Internal Medicine, Tohoku University, School of Medicine
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Ishide Nobumasa
Miyagi Study Group of Acute Myocardial Infarction(Miyagi-Ken Shinkin Kousoku Taisaku Kyogikai)
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Shinozaki Tsuyoshi
First Department of Internal Medicine, Tohoku University School of Medicine
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Kagaya Yutaka
First Department of Internal Medicine, Tohoku University School of Medicine
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Shirato Kunio
First Department Of Internal Medicine Tohoku University School Of Medicine
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Ishide Nobumasa
The 1st.department Of Internal Medicine Tohoku University School Of Medicine
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Ishida Nobumasa
The First Department Of Internal Medicine Tohoku University School Of Medicine
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Ishide Nobumasa
東北大学
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Satoh Masuko
First Department of Internal Medicine, Tohoku University School of Medicine
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Satoh Masuko
First Department Of Internal Medicine Tohoku University School Of Medicine
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Ishide Nobumasa
First Department Of Internal Medicine Tohoku University School Of Medicine
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