Determination of Cardiac Output by Rebreathing Method ; with Special Reference to Its Reliability and Merit in Clinical Use

概要

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The P_<V^^~co_2>, was determined graphically by the rate of rise in CO_2 concentration while rebreathing pure oxygen. The reproducibility of consecutively determined P_<V^^~co_2> was fairly well and it correlated significantly with the Pa_<CO_2>= directly measured from arterial blood. To make the procedure determining the cardiac output strictly non-bloody, Pa_<CO_2> was also determined indirectly by the end-tidal gas analysis. The CO_2 output was measured conventionally. The P_<V^^~co_2> and Pa_<CO_2> were converted to their con-tent with CO_2 dissociation curve for fully oxygenated blood, then the cardiac output was calculated applying these values to the Fick's formula. The range of the cardiac output determined consecutively during an hour was considered small enough to be included within the physiological fluctuation, and the cardiac output thus determined correlated significantly with that by direct Fick method. The cardiac output was significantly different between one another in three groups (healthy, ischemic heart disease and ischemic heart failure). The result agreed with that made by the dye dilution method and apexcardiogram. Having fairly good reproducibility and showing good accordance with the results by the other techniques, it was proved that this indirect Fick method is of great clinical use. Besides, the procedure does not give almost any mental or physical load to subjects.
社団法人日本循環器学会の論文
1968-09-20