THE EFFECTS OF DILTIAZEM HYDROCHLORIDE ON THE CARDIAC CONDUCTION : A Clinical Study of His Bundle Electrogram
スポンサーリンク
概要
- 論文の詳細を見る
The effects of diltiazem hydrochloride, a new Ca^<++> antagonistic antianginal drug, on the cardiac conductivity were evaluated in 10 patients with atherosclerotic heart disease. His bundle electrograms were obtained by catheter technique. R-R, A-H and H-V intervals were measured before and after intravenous administration of diltiazem. Diltiazem acted towards significant prolongation in A-H interval. R-R and H-V intervals were insensitive to diltiazem. Diltiazem did not interrupt the cardiac effects of atropine when A-H prolongation was still observed in the subject pretreated with atropine. In short, diltiazem depresses the conductivity of the atrioventricular node selectively and this is not mediated through vagus tone change. This Ca^<++> antagonist induced A-H prolongation strongly suggests the contribution of Ca^<++> current on the generation of atrioventricular nodal action potential in humans.
- 社団法人日本循環器学会の論文
- 1978-12-20
著者
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Nakaya Haruaki
Clinical Cardiovascular Research Unit. Tonan Hospital
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OYAMA YOHTARO
CLINICAL CARDIOVASCULAR RESEARCH UNIT, TONAN HOSPITAL, SAPPORO
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KANDA KOHICHI
CLINICAL CARDIOVASCULAR RESEARCH UNIT, TONAN HOSPITAL, SAPPORO
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IMAI YOHKO
CLINICAL CARDIOVASCULAR RESEARCH UNIT, TONAN HOSPITAL, SAPPORO
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Satoh Tatsuo
Clinical Cardiovascular Research Unit Tonan Hospital.
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Satoh Tatsuo
Division Of Cardiology Internal Medicine Tonan Hospital
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Satoh Tatsuo
Cardiovascular Research Urait Tonan Hospital
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Oyama Yohtaro
Cardiovascular Research Urait Tonan Hospital
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Satoh Tatsuo
Clinical Cardiovascular Research Unit. Tonan Hospital
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Imai Yohko
Clinical Cardiovascular Research Unit. Tonan Hospital
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Kanda Kohichi
Clinical Cardiovascular Research Unit. Tonan Hospital
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Oyama Yohtaro
Clinical Cardiovascular Research Unit. Tonan Hospital
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Imai Yoko
Clinical Cardiovascular Research Unit Tonan Hospital
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Sato Tatsuo
Tonan Hosp. And 2nd Div. Dept. Of Med. Sch. Of Med. Hokkaido Univ.
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