Pilsicainide Intoxication in a Patient With Dehydration
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概要
- 論文の詳細を見る
An 81-year-old woman developed pilsicainide intoxication associated with dehydration. The patient had been taking pilsicainide(100mg/day)for 1 year because of paroxysmal atrial fibrillation. Her renal function was within normal limits. One week before admission, she was suffering from pneumonia, and had appetite loss, fever, and severe fatigue. Physical examination revealed dehydration. The electrocardiogram(ECG) on admission showed atrioventricular dissociation, idioventricular rhythm with marked QRS widening and QTc prolongation. The plasma concentration of pilsicainide on admission was markedly elevated at 6.2μg/ml, approximately 6times the therapeutic range(0.25-1.0μg/ml). Continuous saline infusion was initiated for the treatment of dehydration, which progressively improved. As a result, sinus rhythm was recovered 2h after admission, and the QRS and JT intervals gradually normalized. This is an interesting case because the proarrhythmia of pilsicainide was induced by dehydration.
- 社団法人日本循環器学会の論文
- 1999-02-20
著者
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Matsuo Shuzo
Division Of Cardiology Department Of Internal Medicine Saga Medical School
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Yano Katsusuke
Third Department of Internal Medicine, Nagasaki University
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Matsuo Shouzo
The Dept. Of Intern. Med Saga Med. School
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Utsunomiya Toshinori
Division of Cardiology, Internal Medicine, Saga Medical School
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Ozeki Shin-ichiro
Department of Cardiology, Saga National Hospital
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Utsunomiya Toshinori
Division Of Cardiology Department Of Internal Medicine Saga Medical School
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Yano Katsusuke
Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Matsuo Shuzo
The Third Dept. Of Intern. Med. Nagasaki Univ. School Of Med.
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Yano Katsusuke
Third Department Of Internal Medicine Nagasaki University
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Matsuo Shuzo
1st Div. Dept. Of Intern. Med. Nagasaki Univ. Sch. Of Med.
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Ozeki Shin-ichiro
Department Of Cardiology Saga National Hospital
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Matsuo Shouzo
Division Of Cardiology Department Of Internal Medicine Saga Medical School
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Matsuo Shuzo
Dept Of Internal Medicine Division Of Cardiology Saga Medical School
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Utsunomiya Toshinori
Division of Cardiology, Department of Internal Medicine, Saga Medical School
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