Relationship Between Brain Atrophy Estimated by a Longitudinal Computed Tomography Study and Blood Pressure Control in Patients With Essential Hypertension

スポンサーリンク

概要

• 論文の詳細を見る

• To evaluate the relationship between blood pressure control and the progression of brain atrophy in the elderly, patients with essential hypertension and brain atrophy were longitudinally evaluated using computerized tomography(CT). The study evaluated 48 patients with essential hypertension aged 46-78 years, and 30 sex-and age-matched normotensive control subjects. The extent of brain atrophy as determined by caudate head index(CHI), the inverse cella media index(iCMI), and Evans'ratio(ER) was estimated twice at an interval of 5-9 years(mean, 6.9 years). The mean annual increases in CHI(ΔCHI), iCMI(ΔiCMI), and ER(ΔER)were evaluated. Mean blood volume in the common carotid artery(BF)and the decrease in BF per year(ΔBF)were also determined. The ΔCHI, ΔiCMI, and ΔER increased with age in the hypertensive subjects as well as the control group across all age groups evaluated. The ΔCHI, ΔiCMI, and ΔER were significantly greater in the patients with essential hypertension in their 50s as compared with the controls. In patients with essential hypertension aged 65 years or older, the ΔCHI, ΔiCMI, and ΔER were significantly lower in the group in whom the blood pressure was controlled within the range of borderline hypertension than the groups in which it was controlled in the range of normal or mild hypertension. In the younger patients under the age of 65 with essential hypertension, blood pressure control did not affect the ΔCHI, ΔiCMI, and ΔER. The ΔCHI, ΔiCMI, and ΔER were significantly correlated with ΔBF in both groups. These findings indicate that control of systolic blood pressure within the range of borderline hypertension may delay the progression of brain atrophy in elderly patients with essential hypertension.

• 社団法人日本循環器学会の論文
• 1999-01-20

著者

• TAKAOKA Minoru

  First Department of Internal Medicine, Nara Medical University

• Takaoka Minoru

  First Department Of Internal Medicine Nara Medical University

• Dohi Kazuhiro

  First Department of Internal Medicine, Nara Medical University

• Dohi Kazuhiro

  First Department Of Internal Medicine And Department Of Clinico-laboratory Diagnostics Nara Medical

• Dohi Kazuhiro

  First Department Of Internal Medicine Nara Medical University

• Dohi Kazuhiro

  First Department Of Internal Medicine

• Dohi Kazuhiro

  The First Department Of Internal Medicine.nara Medical University

• Dohi K

  Nara Medical Univ. Nara Jpn

• Yamamoto Yuta

  First Department Of Internal Medicine Nara Medicial University

• Fukui Rie

  First Department of Internal Medicine, Nara Medical University

• YAMANO Shigeru

  First Department of Internal Medicine, Nara Medical University

• MINAMI Shigetoshi

  First Department of Internal Medicine, Nara Medical University

• Sawai Fuyuki

  First Department of Internal Medicine, Nara Medical University

• Sawai Nobuyuki

  First Department of Internal Medicine, Nara Medical University

• Akai Mayumi

  First Department of Internal Medicine, Nara Medical University

• Nomura Kumiko

  First Department of Internal Medicine, Nara Medical University

• Fukui Rie

  The First Department Of Internal Medicine Nara Medical University

• Fukui Rie

  First Department Of Internal Medicine Nara Medical University

• Akai Mayumi

  First Department Of Internal Medicine Nara Medical University

• Sawai Fuyuki

  First Department Of Internal Medicine Nara Medical University

• Nomura Kumiko

  The First Department Of Internal Medicine Nara Medical University

• Yamamo Shigeru

  First Department Of Internal Medicine Nara Medical University

• Sawai Nobuyuki

  First Department Of Internal Medicine Nara Medical University

• Yamano Shigeru

  The First Depertment Of Internal Medicine Nara Medical University

• Yamano Shigeru

  First Department Of Internal Medicine Nara Medical University

• Minami Shigetoshi

  First Department Of Internal Medicine Nara Medicial University

• Yamano Shigeru

  First Department Of Internal Medicine

関連論文

• Treatment With Recombinant Placental Growth Factor (PlGF) Enhances Both Angiogenesis and Arteriogenesis and Improves Survival After Myocardial Infarction
• Progression of Non-Culprit Coronary Artery Atherosclerosis After Acute Myocardial Infarction in Comparison with Stable Angina Pectoris
• PJ-155 rhPIGF-Treatment Preserved Left Ventricular Function and Inhibited Post-infarct Remodeling by Enhancing Neovascularization and Arteriogenesis(Acute myocardial infarction, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Socie
• Effects of Exercise Training on the Heart Rate Variability and QT Dispersion of Patients With Acute Myocardial Infarction
• Heart Rate Variability and Ventricular Arrhythmia in Clinically Stable Patients With Hypertrophic Cardiomyopathy
• -0816- THE EFFECTS OF ACTIVE PHYSICAL TRAINING ON AUTONOMIC NERVOUS ACTIVITY AFTER ACUTE MYOCARDIAL INFARCTION(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• ENHANCED SHEAR STRESS-INDUCED PLATELET AGGREGATION (SIPA) AT CORONARY SINUS IN PATIENTS WITH UNSTABLE ANGINA
• -P488- THE CORONARY FLOW VELOCITY IN THE GREAT CARDIAC VEIN(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• -0730- RELATIONSHIP BETWEEN THE HEMODYNAMICS IN THE INFARCT-RELATED CORONARY ARTERY AFTER DIRECT PTCA AND RESTENOSIS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• THE VASOMOTION OF INFARCT RELARTED CORONARY ARTERY AFTER DIRECT PTCA AND NO ANGIOGRAPHIC RESTENOSIS : A STUDY USING ACETYLCHOLINE
• FRS-109 Elevated Plasma Level of Placenta! Growth Factor (PIGF) is Correlated with Peripheral Monocyte fraction in Patients with Acute Myocardial Infarction(Acute Coronary Syndrome (IHD) : FRS13)(Featured Research Session (English))
• Catastrophic Antiphospholipid Antibody Syndrome in Systemic Lupus Erythematosus: An Autopsy Case Report of a Young Woman
• Contribution of Asynchronous Left Ventricular Long axis Motion to Left Ventricular Outflow Obstruction in Patients with Hypertrophic Cardiomyopathy
• Preload reduction by a single hemodialysis unmasks abnormal left ventricular inflow jet dynamics and early diastolic incoordinate long axis motion in patients on maintenance hemodialysis
• A Case of Eosinophilic Myocarditis Complicated by Kimura's Disease(Eosinophilic Hyperplastic Lymphogranuloma)and Erythroderma
• P582 CONTRIBUTION OF THE VELOCITY PROFILE OF THE LEFT VENTRICULAR OUTFLOW TRACT FOR THE CALCULATION OF THE STROKE VOLUME
• 0564 GENE POLYMORPHISM OF ANGIOTENSIN II TYPE 1 RECEPTOR AND ANGIOTENSINOGEN IN PATIENTS WITH CORONARY ARTERY DISEASE
• 0395 THE CORRELATION BETWEEN INTRACORONARY ULTRASOUND AND PATHOLOGICAL FINDINGS ON NECROTIC CORE IN ADVANCED PLAQUES OF AUTPSIED CORONARY ARTERY
• A Case of Dilated Cardiomyopathy With Abhormal Atrioventricular Condnction 5 Years Before the Appearance of Left Ventricular Systolic Dysfnnction
• Absence of Myocardial ^I-BMIPP Uptake in the Presence of a Normal Coronary Angiogram and Normokinetics on a Left Ventriculogram
• P648 Magnetic resonance velocity mapping of normal transtricuspid velocity profiles
• Central retinal vein occlusion and cerebellar infarction complicating systemic lupus erythematosus : a case report
• Role of Secreted Protein Acidic and Rich in Cysteine (SPARC) in Patients with Diabetic Nephropathy
• -0389-STUDY OF THE RELATIONSHIP BETWEEN THE HEMODYNAMICS IN THE BASAL CEREBRAL ARTERIES BY TRANSCRANIAL DOPPLER ARTERIOGRAPHY AND ATHEROGENIC FACTORS
• DIAGNOSTIC IMAGING OF THE BASAL CEREBRAL ARTERIES BY THREE DIMENSIONAL TRANSCRANIAL DOPPLER SCANNER : Pulmonary, Peripheral, Cerebral Circulation : 53 Annual Scientific Meeting, Japanese Circulation Society
• Primary Focal Segmental Glomerulosclerosis: Clinical Course, Predictors of Renal Outcome and Treatment
• Acute Left Ventricular Failure with Pulmnary Edema Following Pericardiocentesis for Cardiac Tamponade : A Case Report
• Autonomic nervous activity in hypertrophic cardiomypathic patients with severe ventricular arrhythmias assessed by spectral analysis of heart rate variability
• White-Coat Hypertension Contributes to the Presence of Carotid Arteriosclerosis
• IgA nephropathy with myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO ANCA): a discrepancy between the histological activity and MPO ANCA
• Asymptomatic Cerebrovascular Lesions Detected by Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Lacking a History of Neuropsychiatric Events
• Relationship Between Brain Atrophy Estimated by a Longitudinal Computed Tomography Study and Blood Pressure Control in Patients With Essential Hypertension
• Anorexia Nervosa with Left Atrial Failure
• Apical Hypertrophy with Massive Myocardial Fibrosis: Compatison with Electrocardiographic Changes
• P782 INTRAVENTRICULAR BLOOD FLOW ANALYSIS USING ULTRASOUND BASED COMPUTATIONAL FLUID DYNAMICS MODELS
• 0733 DISTRIBUTION OF APOPTOTIC MACROPHAGE IN PLAQUES OF ACUTE CORONARY SYNDROME (ACS)
• 0350 ASYMPTOMATIC CEREBROVASCULAR INVOLVEMENTS IN PATIENTS WITH SLE ESTIMATED BY BRAIN MRI AND SPECT
• PE-323 Myocardial Infarction Leads to Accelerated Neointimal Hyperplasia after Vascular Injury.(Atherosclerosis, Basic 5 (IHD) : PE55)(Poster Session (English))
• -0772- CORONARY ATHEROSCLEROTIC LESIONS RESECTED BY DIRECTIONAL CORONARY ATHERECTOMY IN ISCHEMIC HEART DISEASES : A MORPHOLOGIC AND IMMUNOHISTOCHEMICAL STUDY(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• ASSESSMENT OF AUTONOMIC NERVOUS RESPONSE TO TRANSIENT MYOCARDIAL ISCHEMIA BY POWER SPECTRAL ANALYSIS OF HEART RATE VARIABILITY
• A Unique Case of Renovascular Hypertension Caused by Combined Renal Artery Disease
• Measurement of Interleukin - 1βmRNA Levels in Peripheral Blood Mononuclear Cells of Patients with Chronic Renal Failure
• Cardiac Overexpression of Placental Growth Factor Correlates to Improvement of Chronic Phase Left Ventricular Function in Patients with Myocardial Infarction (Acute Myocardial Infarction, Clinical (Pathophysiology) 7 (IHD), The 69th Annual Scientific Meet
• Assessment of Coronary Artery Stent by 16-Detector Multislice Computed Tomography(X-ray/CT/MRI/DSA 6 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Myocardial Infarction Accelerates Remote Region Vascular Remodeling in a Model of Post-Angioplasty Restenosis(Restenosis after Angioplasty, Basic/Clinical 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• THE INVESTIGATION TO REVEAL THE MECHANISM FOR CARDIAC INVOLVEMENT IN WBN/Kob RAT
• IMMUNOHISTOCHEMICAL LOCALIZATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS IN CORONARY ARTERY : CLINICAL DATA AND MORPHOLOGICAL FEATURES
• Preventive effects of a New Angiotensin II Receptor Antagonist (TCV-116) on Myocardial Hypertrophy in Spontaneously Hypertensive Rats
• Preventive effect of denopamine on myocardial damage in BIO 14.6 cardiomyopathic hamsters : Evaluation through examining β1-adrenergic receptors, the myocardial adenylate cyclase (AC) activity and CAMP concentration.
• THE CORRELATION BETWEEN INVERTED T WAVE CHANGES IN ACUTE MYOCARDIAL INFARCTION AND REGIONAL WALL MOTION ABNORMALITIES IN THE CHRONIC PHASE
• PREVENTIVE EFFECT OF DENOPAMINE ON MYOCARDIAL DAMAGE IN BIO 14.6 CARDIOMYOPATHIC HAMSTERS:EVALUATION THROUGH EXAMINING β_1-ADRENERGIC RECEPTORS, THE MYOCARDIAL ADENYLATE CYCLASE (AC)ACTIVITY AND cAMP CONCENTRATION
• IMMUNOHISTOCHEMICAL STYDY OF CARDIAC TISSUE USING AN ANTI-AGEs ANTI-BODY
• ADVANCED GLYCOSYLATION END PRODUCTS(AGEs)MAY BE INVOLED IN THE PATHOGENESIS OF CORONARY ATHEROSCLEROSIS IN DIABETIC MELLITUS
• -0290-EVALUATION OF MYOCARDIAL ABNORMALILIES IN COLLAGEN DISEASES BY THALLIUM-201 MYOCARDIAL SCINTIGRAPHY
• FRS-065 Association Between the Hpall Arial Natriuretic Peptide Gene Polymorphism and Carotid Atherosclerosis in Patients with Essential Hypertension(Atherosclerosis (IHD) : FRS8)(Featured Research Session (English))
• Association of Paraoxonase Gene Polymorphism with Left Ventricular Hypertrophy and Carotid Atherosclerosis in Patients with Essential Hypertension
• Role of tissue inhibitors of metalloproteinase in diabetic nephropathy
• Diagnostic significance of urinary transferrin in diabetic nephropathy
• Diagnostic significance of urinary fibronectin in diabetic nephropathy
• Inhibitory Effect of Efonidipine, a T-type and L-type Calcium Channel Blocker, on Aldosterone Secretion in H295R Cells (Hypertension, Basic 4(H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Vascular Remodeling of the Carotid Artery in Patients with Untreated Essential Hypertension Increases with Age
• Associations of Plasma Endothelin Concentration with Carotid Atherosclerosis and Asymptomatic Cerebrovascular Lesions in Patients with Essential Hypertension
• P037 CONTRIBUTION OF LONG AXIS MOTION OF LEFT VENTRICULAR OUTFLOW TO CALCULATION OF LEFT VENTRICULAR STROKE VOLUME
• 0606 INVESTIGATION OF CORONARY HEMODYNAMICS FOR THE PREDICTION OF RESTENOSIS AFTER PERCUTANEOUS TRANS-LUMINAL CORONARY ANGIOPLASTY
• T-type and L-type Ca Channel Blocker Efonidipine Reduces Ventricular Premature Contractions in Human (Arrhythmia, Pharmacological Therapy 3 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

もっと見る 閉じる

スポンサーリンク