MYOCARDIAL BLOOD FLOW, ALTERNANS OF ST SEGMENT ELEVATION, CONDUCTION DELAY AND VENTRICUIAR ARRHYTHMIA DURING ACUTE MYOCARDIAL ISCHEMIA WITH AND WITHOUT RETROGRADE BLOOD FLOW IN CANINE HEARTS
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概要
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The technique of retrograde blood flow has been shown to decrease collateral flow into the ischemic myocardium, and to cause severe myocardial ischemia in dogs. Ischemia with retrograde blood flow in dogs is similar to ischemia in human hearts. Therefore, we examined the effect of retrograde blood flow on myocardial blood flow, ST segment elevation, alternans of ST segment elevation, conduction delay and ventricular arrhythmia in dogs. Sixty dogs were divided into two groups. In group A (N=32), the left anterior descending coronary artery was occluded for 10 min. In group B (n=28), ischemia was induced by the technique of retrograde blood flow for 10min. During ischemia, the myocardial blood flow at the ischemic zone measured by a H_2 gas clearance method was 11.2~1.6 in group A and 5.7±0.7ml/min/100g in group B (p<0.01). The maximal ST segment elevation was 13.6±1.9 in group A and 27.2±2.1mV in group B (p<0.001); the maximal alternans of ST segment elevation was 5.3±1.1 in group A and 10.1±1.4mV in group B (p<0.01); the maximal conduction delay was 51.6±8.4 in group A and 111.1±6.2 msec in group B (p<0.001); and the incidences of ventricular premature beats (>5/min), ventricular tachycardia and fibrillation were 34%, 41% and 22% in group A, and 68%, 79% and 25% in group B (p<0.01, p<0.01 and not significant, respectively). It is concluded that ischemia with retrograde blood flow can be used to examine occlusive and reperfusion ventricular arrhythmia in dogs. because the incidences of ventricular premature beats and ventricular tachycardia were high, but that of ventricular fibrillation was not high despite the severe ischemia.
- 社団法人日本循環器学会の論文
- 1991-06-20
著者
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NAGAMOTO YASUO
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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OHKITA TAKASHI
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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FUJITA MASASUKE
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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KUROIWA AKIO
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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Kuroiwa Akio
Moji Rosai Hospital
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OHKITA Takashi
Second Department of Internal Medicine
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Kuroiwa Akio
The Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environ
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Kuroiwa Akio
The 2nd Depart.of Int.med. Univ.of Occupational And Environmental Health
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Ohokita Takashi
The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health
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Nagamoto Yasuo
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Nagamoto Yasuo
The 2nd Department Of Internal Medicine School Of Medicine University Of Occupational And Environmen
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Fujita Masasuke
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Kuroiwa Akio
Department Of Internal Medicine Moji Rosai Hospital
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Kuroiwa Akio
University Of Occupational And Environmental Health School Of Medicine
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Kuroiwa Akio
Second Department Of Internal Medicine University Of Occupational And Environ-mental Health School O
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Kuroiwa Akio
The 2nd Department Of Internal Medicine School Of Medicine University Of Occupational And Environmen
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FURUNO YOUICHIRO
The 2nd Department of Internal Medicine, University of Occupational and Environmental Health, School
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Furuno Youichiro
The 2nd. Department Of Internal Medicine University Of Occupational And Envirommental Health
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Fujita Masasuke
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Furuno Youichiro
The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health School O
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Kuroiwa Akio
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Fujita Masasuke
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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