ELECTROPHYSIOLOGIC CHANGES BEFORE ONSET OF VENTRICULAR TACHYARRHYTHMIAS DURING PARTIAL REPERFUSION FOLLOWING SEVERE MYOCARDIAL ISCHEMIA IN DOGS
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概要
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We examined the electrophysiologic changes before an onset of ventricular tachyarrhythmia during partial reperfusion following severe myocardial ischemia. The left anterior descending coronary artery was occluded and cannulated below the occluded portion in 26 dogs. To deplete collateral flow into the ischemic myocardium, retrograde blood flow was induced for 20 min. Then, in all dogs except 7 with ventricular fibrillation during retrograde blood flow, partial reperfusion through collateral flow into the ischemic myocardium was produced by stopping the retrograde flow. Within 2 min of partial reperfusion, sustained ventricular tachycardia (VT) occurred in 7 dogs (group A) and non-sustained VT degenerating ventricular fibrillation occurred in 11 dogs (group B) of the remaining 12 dogs. In 6 dogs of group A and 9 of group B, epicardial conduction block appeared 5.0±2.2 and 3.5±1.3 min after ischemia. This was followed by fractionated electrical activities 15.2±3.2 and 11.7±3.3 min after ischemia. In group A, the fractionation had a slight change in configuration and a small increase in amplitude before the onset of VT during reperfusion; in group B, new deflections with large amplitude emerged before it. There was a significant difference in the amplitude (0.38±0.2 vs 0.67±0.3 mV, p<0.025) between the 2 groups, although there was no significant difference in the amplitude (0.33±0.2 vs 0.23±0.1 mV) of the fractionation just before reperfusion. Our results show that slight improvement in fractionation induces sustained VT, and new deflections induce non-sustained VT degenerating ventricular fibrillation, even during partial reperfusion.
- 社団法人日本循環器学会の論文
- 1992-10-20
著者
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Abe Haruhiko
The Second department of Internal Medicine, University of Occupational and Environmental Health
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Abe Haruhiko
The 2nd Department of Internal Medicine, University of Occupational and Environmental Health (UOEH)
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Abe Haruhiko
The Second Department Of Internal Medicine University Of Occupational And Environmental Health
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Abe Haruhiko
The 2nd Department Of Internal Medicine School Of Medicine University Of Occupational And Environmen
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KURIYAMA MASAMI
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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NAGAMOTO YASUO
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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OHKITA TAKASHI
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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FUJITA MASASUKE
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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KUROIWA AKIO
The 2nd Department of Internal Medicine, School of Medicine, University of Occupational and Environm
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Kuroiwa Akio
Moji Rosai Hospital
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OHKITA Takashi
Second Department of Internal Medicine
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Abe Haruhiko
The 2nd Depart.of Int.med. Univ.of Occupational And Environmental Health
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Kuroiwa Akio
The Second Department Of Internal Medicine School Of Medicine University Of Occupational And Environ
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Kuroiwa Akio
The 2nd Depart.of Int.med. Univ.of Occupational And Environmental Health
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Ohokita Takashi
The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health
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Nagamoto Yasuo
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Nagamoto Yasuo
The 2nd Department Of Internal Medicine School Of Medicine University Of Occupational And Environmen
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Fujita Masasuke
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Kuroiwa Akio
Department Of Internal Medicine Moji Rosai Hospital
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Kuroiwa Akio
University Of Occupational And Environmental Health School Of Medicine
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Kuroiwa Akio
Second Department Of Internal Medicine University Of Occupational And Environ-mental Health School O
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Kuroiwa Akio
The 2nd Department Of Internal Medicine School Of Medicine University Of Occupational And Environmen
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Kuriyama Masami
The 2nd Department Of Internal Medicine University Of Occupational And Environmental Health
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Abe Haruhiko
The Second Department Of Internal Medicine University Of Occupational And Environmental Health Japan
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Fujita Masasuke
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Kuroiwa Akio
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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Fujita Masasuke
Second Department Of Internal Medicine University Of Occupational And Environmental Health School Of
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