Augmentation of Eicosanoids in Ischemic Heart Muscle in Dogs : its Role in the Deterioration of the Ischemic Lesion : SYMPOSIUM ON PATHOPHYSIOLOGY IN THE EARLY STAGE OF ACUTE MYOCARDIAL INFARCTION AND ITS TREATMENT : 51th Annual Scientific Session of the
スポンサーリンク
概要
- 論文の詳細を見る
The dissolution of infarcted myocardium occurs after the infiltration of leukocytes. In the search for a mechanism of the leukocyte infiltration, we measured the production of lipoxygenase metabolites of arachidonic acid in the canine myocardium after ligation of the circumflex branch of the left coronary artery. At least 2 lipoxygenase products, namely 5- and 12-hydroxy-eicosatetraenoic acids (HETEs), were augmented in myocardium subjected to ischemia lasting more than 6 hours, with levels of the latter being raised much more than the former. Augmentation of the HETEs in ischemic myocardium appeared to occur prior to any significant infiltration of leukocytes. More than 12 hours after coronary ligation, the infiltration of leukocytes became prominent and an increase in 12-HETE was observed. Calcium content in the infarcted myocardium appeared to be increased several hours before the increase in 12-HETE. These data suggest that the initial increment in 12-HETE may result from it being a product of infarcted myocardium, where Ca^<2+> is accumulated in the cell, and that the increased HETEs work as a leukocyte chemoattractant in infarcted myocardium. This hypothesis is supported by the independent experiment which showed that cultured cardiomyocytes produced lipoxygenase metabolites of arachidonic acid, including 12-HETEs etc, which exhibited neutrophil-chemoattractant activity when they were challenged by calcium ionophore and/or arachidonic acid. Azelastine-HCl, a lipoxygenase inhibitor, attenuated not only the above production of HETEs from the cardiomyocytes, but also production of HETEs and infiltration of neutrophils in ischemic myocardium, resulting in attenuation of the fibrous scar of infarcted myocardium.
- 社団法人日本循環器学会の論文
- 1988-07-20
著者
-
Goshima Kiyota
Kobegakuin University
-
Shibata Nobuhiko
The Center For Adult Disease
-
Shibata Nobuhiko
The Center For Adult Diseases Department Internal Medicine
-
AKAGAMI HIROTA
The Center for Adult Diseases, Department Internal Medicine
-
SANMA HIDEYUKI
Eisai Co., Ltd., Tokyo Research Labo-ratory
-
Akagami Hirota
The Center For Adult Diseases Department Internal Medicine
-
Sanma Hideyuki
Eisai Co. Ltd. Tokyo Research Labo-ratory
関連論文
- Effect of Alfalfa Grass on the Experimental Atherosclerosis of the Lanolin Fed Rabbits
- Pathological Studies of Coronary Atherosclerosis : Especially, of Sclerosis of Intramusclar Coronary Arteries
- AN APPROACH TO CARDIAC ARRYTHMIA AND INTERCELLULAR CONDUCTION DISTURBANCE FROM CULTURED HEART MUSCLE CELLS
- Identification of Myosin A, Actin and Native Tropomyosin Constituting of Arterial Contractile Protein (Myosin B) and Their Characteristics
- ELECTRON MICROSCOPIC STUDIES ON THE MYOFIBRIL-LIKE FIBRILS IN THE MESANGIAL CELLS AND THE GLOMERULAR EPITHELIAL CELLS IN RAT RENAL CORTEX. (II)
- ELECTRON MICROSCOPIC STUDIES ON THE MYOFIBRILS IN THE EPITHELIAL CELLS OF THE BOWMAN'S CAPSULE AND OF PROXIMAL TUBULES IN RAT RENAL CORTEX (First Report)
- -1-PREDICTION OF SEVERITY OF CORONARY ARTERY DISEASE USING ST SLOPE RESPONSE ON TREADMILL EXERCISE TEST : Excercise Test : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- 190) Effect of Glucocorticoid upon Serum LDH Isozyme. S-GOT, S-GPT and Cardiac Na-K Sensitive ATP-ase in Myocardial Infarction
- Augmentation of Eicosanoids in Ischemic Heart Muscle in Dogs : its Role in the Deterioration of the Ischemic Lesion : SYMPOSIUM ON PATHOPHYSIOLOGY IN THE EARLY STAGE OF ACUTE MYOCARDIAL INFARCTION AND ITS TREATMENT : 51th Annual Scientific Session of the
- A Consideration of a Mechanism of Augmentation of Peripheral Vascular Resistance in Hypertension : Presence of F-actin Filament in Renal Arterioles and Electrolytes Contents in Arterial Wall in Hypertensive Rat (Goldblatt Type)
- A MECHANISM OF THROMBUS-FORMATION : INTERACTION OF CONTRACTILE PROTEINS IN PLATELET AND FIBRIN NETWORK DURING CLOT RETRACTION : PTCA, Thrombosis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- DEGRADATION OF STRUCTURAL PROTEINS IN REPERFUSED ISCHEMIC MYOCARDIUM AND EFFECT OF PROTEASE-INHIBITOR ON THE DEGRADATION : Cardiac Metabolism (I) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- DEGRADATION PROCESS OF CELLULAR ELEMENTS IN THE INFARCTED MYOCARDIUM AND EFFECT OF PROTEINASE INHIBITER ON THE PROCESS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Myocardial Metabolism Biochemistry
- Ca^ -CALMODULIN DEPENDENT MYOSIN LIGHT CHAIN KINASE FROM ARTERIES. ITS ROLE IN ARTERIAL ACTOMYOSIN-TROPOMYOSIN SYSTEM AND MODIFIACTION BY cAMP KINASE : Blood Vessels : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE