THROMBOXANE SYNTHETASE INHIBITION AND PULMONARY RESPONSE TO HYPOXIA IN CONSCIOUS ADULT SHEEP
スポンサーリンク
概要
- 論文の詳細を見る
This study investigated the effects of a thromboxane synthetase inhibitor (OKY-046) and a cyclooxygenase inhibitor (ketoprofen) on hypoxic pulmonary vasoconstriction in conscious adult sheep in order to evaluate the physiological role of thromboxane and other cyclooxygenase products. In addition, we studied the effects of histamine H_1 (chlorpheniramine) and H_2 antagonists (cimetidine) on hypoxic pulmonary vascular tone. Hypoxia caused a 37% rise in pulmonary arterial pressure (p < 0.05) and a 36% increase in pulmonary vascular resistance (p < 0.05). Pretreatment with intravenous OKY-046 10 mg /kg or ketoprofen 2 mg/kg had no effect on normoxic pulmonary vascular tone and inhibited the increase in plasma TXB_2 concentration during hypoxia without affecting the pulmonary pressor response to hypoxia. Cimetidine produced an increase in hypoxic pulmonary pressor response to hypoxia. Cimetidine produced an increase in hypoxic pulmonary vascular tone when individual members of the group were compared, but there was no statistically significant difference when the group was compared to the control study. Chlorpheniramine had no effect on hypoxic pulmonary tone. These data suggest that hypoxic pulmonary vasconstriction is not mediated by release of TXA_2, that hypoxic vascular tone is not modulated by cyclooxygenase products, and that the histamine H_2 receptor may play a modulating role in hypoxic pulmonary vasconstriction in conscious adult sheep.
- 社団法人日本循環器学会の論文
- 1988-01-20
著者
-
田中 紘一
Research Reactor Institute Kyoto University
-
酒井 秋男
長野県八千穂中学校
-
田中 紘一
長岡技術科学大学 工学部機械系
-
Sakai Akio
Environmental Physiology Shinshu University School Of Medicine
-
酒井 秋男
信州大医学部環境生理学教室
-
Kobayashi Toshio
The Department Of Internal Medicine
-
Ueda Gou
Environmental Physiology Shinshu University School Of Medicine
-
Ueda Gou
Research Center On Aging And Adaptation Shinshu University School Of Medicine
-
Kusama Shozo
The Department Of Internal Medicine
-
YOSHIMURA KAZUHIKO
The Department of Internal Medicine
-
Sakai A
Shinshu Univ. School Of Medicine
-
Sakai Akio
Graduate School Of Medicine Research Center On Aging And Adaptation Shinshu University
-
Tatsumi Koichiro
Department Of Respirology (b2) Graduate School Of Medicine Chiba University
関連論文
- Magnetic Field Evolution of a Novel Phase Transition in CeOs_4Sb_ : ^Sb NMR Study
- Development of ^Eu Time-Domain Interferometry and Its Application for the Study of Slow Dynamics in Ionic Liquids
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- A spectrometer for Rayleigh scattering of Mossbauer radiation using synchrotron radiation
- Spin Ordering in LaFeAsO and Its Suppression in Superconductor LaFeAsO_F_ Probed by Mossbauer Spectroscopy(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Magnetic Excitations in Heavy Electron State of Filled Skutterudite Pr_xLa_Fe_4P_ (x=1.00 and 0.85)(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Fabrication of Optoelectronic Devices in Lithium Fluoride Crystals by Interfering Femtosecond Laser Pulses
- Dependence of Incoherent Nuclear Resonant Scattering of Synchrotron Radiation on the Number of Resonant Nuclei(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Generation and Application of Ultrahigh Monochromatic X-ray Using High-Quality ^FeBO_3 Single Crystal
- Nuclear Resonant Scattering of Synchrotron Radiation by Yb Nuclides(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- ^Co-NMR Probe for Stepwise Magnetization and Magnetotransport in SrCo_6O_ with Metallic Kagome Layer and Triangular Lattice with Local Moments(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- 5-2 チップマウンタにおけるリスクアセスメントの実施例(セッション5 安全(事例))(日本信頼性学会第17回秋季信頼性シンポジウム報告)
- 5-1 大学における研究室の安全管理と安全技術 : 教育用ロボットの安全化事例(セッション5 安全(事例))(日本信頼性学会第17回秋季信頼性シンポジウム報告)
- 5-2 チップマウンタにおけるリスクアセスメントの実施例(セッション5 安全性(事例),第17回秋季信頼性シンポジウム)
- 5-1 大学における研究室の安全管理と安全技術 : 研究用ロボットの安全化事例(セッション5 安全性(事例),第17回秋季信頼性シンポジウム)
- Effects of Charge Disproportionation on the Phonon Density of States in Fe Perovskites(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Effects of Charge Disproportionation on the Phonon Density of States in Fe Perovskites
- ナノメニスカス架橋付着力に及ぼす表面粗さの影響
- Enhancement of Incoherent Elastic Scattering with Magnetic Ordering in the Energy Spectra of Nuclear Resonant Scattering(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- 機械安全の経済性 : リスクとコストの関係を考える(安全の説明責任-試される技術者のState of the art-)
- 鉄鋼製造現場の安全と責任 : 安全技術と安全訓練
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Genuine Phase Diagram of Homogeneously Doped CuO_2 Plane in High-T_c Cuprate Superconductors(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- 機械安全設計原則について
- Multiband Superconductivity in Filled-Skutterudite Compounds (Pr_La_x)Os_4Sb_ : An Sb Nuclear-Quadrupole-Resonance Study(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- A Possible Novel Magnetic Ordering in SmRu_4P_(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- A Possible Novel Magnetic Ordering in SmRu_4P_(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Novel Phase Transition Near the Quantum Critical Point in the Filled-Skutterudite Compound CeOs_4Sb_ : An Sb-NQR Study(Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- Novel Phase Transition Near the Quantum Critical Point in the Filled-Skutterudite Compound CeOs_4Sb_ : An Sb-NQR Study(Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- 410 ナノインデンテーションによるアクリルコーティング薄膜のキャラクタリゼーション
- 410 ナノインデンテーションによるアクリルコーティング薄膜のキャラクタリゼーション
- A. ノイドルファ著「安全な機械の設計」を翻訳して考えたこと
- 固定層および流動層から成るPFPE潤滑膜の摩耗耐久特性
- 固定層および流動層から成るPFPE潤滑膜の摩耗耐久特性
- 固定層および流動層から成るPFPE潤滑膜の摩擦特性
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- Mossbauer Spectroscopy of La_Ca_FePO and LaFeAsO_F_ under External Magnetic Field and Nuclear Resonant Inelastic Scattering of La_Ca_FePO(Condensed matter: electronic structure and electrical, magnetic, and optical prop
- 713 オブザーバ理論によるセンサ系の冗長化
- 606 銅薄膜の変形挙動
- 長岡技術科学大学における産学共同
- 簡便なナノインデンテーション試験結果の解析法開発と各種試験機の性能調査
- 324 無電解NiPメッキの力学特性におよぼす熱処理および粒子分散の影響(OS 薄膜特性)
- K-0633 複合コーティング膜の弾性率におよぼす硬質または軟質粒子の分散効果(S06-1 膜質の応力解析とキャラクタリゼーション)(S06 コーティング材の力学特性と損傷機構)
- Nuclear Resonant Quasielastic Scattering from Fe Cations in Nafion Membranes : Effect of Dynamics in a Short Time Range : Condensed Matter: Structure, etc.
- Determination of the Density and the Thickness of SiO_2 Films Using Extremely Asymmetric X-Ray Diffraction
- 差動光強度変換型ギャップセンサの試作
- 差動型光ファイバー変位計による透明ガラス表面の検出
- Thermoelectric Power and Hall Effect in Co-Al-O Granular Films
- (5)AFM超微小硬さ試験機による弾性常数と降伏応力の測定
- 差動型光ファイバー変位計の作動距離
- 差動型光ファイバー変位計の幾何光学解析
- ナノインデンテーション試験による薄膜の力学特性評価
- 変位制御型ナノインデンテーション試験機の開発(第2報)
- ナノインデンテーション試験の誤差要因
- 660 19Cr4Ni 二相ステンレス鋼の高温ねじり変形挙動におよぼす Cu の影響(ステンレス鋼 (II) : 耐食性, 磁性, 機械的性質, 材料, 日本鉄鋼協会第 112 回(秋季)講演大会)
- 差動型光ファイバー変位計の試作
- ^Fe Mossbauer Spectroscopic Study of U_6Fe : Condensed Matter: Electronic Properties, etc.
- Pressure Study of Superconducting Oxypnictide LaFePO(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- ^As-NMR Studies on LaFeAsO_F_x (x=0.14) under a Pressure of 3GPa(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Superconductivity under High Pressure in LaFeAsO(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Possible Unconventional Superconductivity in Iron-Based Layered Compound LaFePO : Study of Heat Capacity(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Electronic Structure and Electron Correlation in LaFeAsO_F_x and LaFePO_F_x(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Evolution from Itinerant Antiferromagnet to Unconventional Superconductor with Fluorine Doping in LaFeAs(O_F_x) Revealed by ^As and ^La Nuclear Magnetic Resonance(Condensed matter: electronic structure and electrical, magnetic, and optical p
- Superconductivity of LaFe_Co_yAsO_F_x(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Isotope Effect on Superconducting Transition Temperature of Na_xCoO_2・yH_2O(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- NMR Studies of Successive Phase Transitions in Na_CoO_2 and K_CoO_2(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Co-NMR Knight Shift of Na_xCoO_2・yH_2O Studied in Both Superconducting Regions of the T_c-ν_ Phase Diagram Divided by the Nonsuperconducting Phase(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- T-3ν_Q Phase Diagram of Hydrated Cobalt Oxides Na_xCoO_2・yH_2O(Condensed matter : electronic structure and electrical, magnetic, and optical properties)
- Magnetic Behavior of Spin-1/2 Frustrated System Hg_2Cu_2F_6S(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Successive Magnetic Transitions of the Kagome Staircase Compound Co_3V_2O_8 Studied in Various Magnetic Fields(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Ferroelectric Transition Induced by the Incommensurate Magnetic Ordering in LiCuVO_4(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Existence of Co^ Low-Spin State in TbBaCo_2O_(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Multidetector-Row Computed Tomography Management of Acute Pulmonary Embolism
- Elastic Constant Determinations of SiC/NiP Composite Coating by Surface Acoustic Wave and Nano-indentation
- Gender Differences in Chronic Thromboembolic Pulmonary Hypertension in Japan
- Dilatation of Bronchial Arteries Correlates With Extent of Central Disease in Patients With Chronic Thromboembolic Pulmonary Hypertension
- Survival and Quality of Life for Patients With Peripheral Type Chronic Thromboembolic Pulmonary Hypertension
- Spontaneous Disappearance of a Pulmonary Lesion in a Patient with Active Wegener's Granulomatosis
- Decreased Lipoprotein Lipase in Obstructive Sleep Apnea Syndrome
- Angiotensin-Converting Enzyme Gene Polymorphisms and Prognosis in Chronic Thromboembolic Pulmonary Hypertension
- Vascular Endothelial Growth Factor in Obstructive Sleep Apnea Syndrome
- Continuous Positive Airway Pressure Therapy and Tracheostomy for Multiple System Atrophy Accompanied by Sleep Apnea-hypopnea Syndrome
- Placement of Metallic Stents for Critical Airway Stenosis Due to Malignant Diseases
- Thermoradiotherapy for local control of chest wall invasion in patients with advanced non-small cell lung cancer
- 同心円テクスチャを持つハードディスクの真実接触面積とトライボロジ特性
- Mo を含む Ni 基単結晶超耐熱合金の合金設計
- Pressure-Induced Superconductivity in Iron Pnictide Compound SrFe_2As_2
- Superconducting Transition in Electron-Doped 12CaO・7Al_2O_3
- Superconducting Gap and Pseudogap in Iron-Based Layered Superconductor La(O_F_x)FeAs(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- 窒化けい素および炭化けい素の大気中高温転がり疲労特性
- 207 Si_3N_4およびSiCの高温転がり疲労特性(セラミックスの高温特性)