Relationship between Cellular Calcium and Catecholamine on Myocardial Contractility
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概要
- 論文の詳細を見る
Positive inotropic action of norepinephrine were demonstrated in rabbit heart that was perfused by solution containing various calcium concentration. In these experiments, the changes of calcium content in subcellular fractions of myocardium were observed. 1) The calcium concentration in each subcellular fraction of myocardium was increased in the state of increasing contractile force by norepinephrine. Especially, there are similar pattern of changes between calcium concentration in heavy microsome fraction and contractile force of myocardium. 2) Increase of cardiac rate had no effects on the changes of calcium concentration in myocardium. These phenomena induced by norepinephrine were inhibited by pretreatment of propranolol. Thus, it should be emphasized that calcium ion in cardiac sarcoplasmic reticulum plays an important role in increasing contractile force by norepinephrine.
- 社団法人日本循環器学会の論文
著者
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Ueba Yasuyuki
Department of Internal Medicine, Division I, Kobe University School of Medicine
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Ueba Yasuyuki
Department Of Internal Medicine Division 1 Kobe University School Of Medicine
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Ueda Yasuyuki
Department Of Internal Medicine Division I Kobe University School Of Medicine
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