EFFECTS OF GLUCAGON, PROSTAGLANDIN E_1 AND DIBUTYRYL CYCLIC 3',5'-AMP UPON THE TRANSMEMBRANE ACTION POTENTIAL OF GUINEA PIG VENTRICULAR FIBER AND MYOCARDIAL CONTRACTILE FORCE
スポンサーリンク
概要
- 論文の詳細を見る
Effects of glucagon, prostaglandin El and dibutyryl cyclic 3',5'-AMP upon the transmembrane action potential and the myocardial contractile force were investigated by using the isolated, perfused guinea pig heart by Langendorff's technique. The positive chronotropic and inotropic actions were observed by administering these agents into perfusion-cannula, and these effects were not blocked by propranolol. All of these agents produced shortening of the repolarization phase 2 (plateau phase) and increased the membrane resting potential in magnitude. The possible mechanisms underlying these changes is discussed in the light of cardiac cellular physiology and of the action of cyclic 3',5'-AMP in the two messenger system.
- 社団法人日本循環器学会の論文
著者
-
Kobayashi Toshiji
Department Of Internal Medicine National Cancer Hospital
-
NAKAYAMA RYU
Department of Medical Cardiology, National Cardiovascular Center
-
Nakayama Ryu
Department Of Internal Medicine National Cancer Hospital
-
Kimura Kiyoji
Department of Internal Medicine, National Cancer Hospital
-
Kimura Kiyoji
Department Of Internal Medicine National Cancer Hospital
-
KIMURA Kiyoji
Department of Clinical Oncology, Nagoya Memorial Hospital
関連論文
- A Study on the Transmural Conduction Velocity of Activation Front in the Left Ventricle of RBBB Patients : CLINICAL APPLICATION OF BODY SURFACE MAPPING
- THE EFFECT OF VENTRICULAR HYPERTROPHY ON THE VENTRICULAR TRANSMURAL CONDUCTION VELOCITY OF RBBB PATIENTS : Electrocardiography・Vectorcardiography II : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- RELATIONSHIP BETWEEN THE AMPLITUDE OF VOLUME PULSE WAVE AND PULSE TRANSMISSION VELOCITY : PROCEEDINGS OF THE 37TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CLINICAL MEANING OF THE FINGER-TIP PLETHYSMOGRAPHY
- POSITIVE CHRONOTROPIC AND INOTROPIC ACTIONS OF NEW ANTITUMOR AGENT ADRIAMYCIN AND ITS CARDIOTOXICITY : ITS SPECIAL REFERENCES TO MYOCARDIAL CONTRACTILE FORCE AND THE CHANGE OF THE TRANSMEMBRANE ACTION POTENTIAL
- PHARMACOLOGICAL AND ELECTROPHYSIOLOGICAL ACTIONS OFPROSCILLARIDIN A THE MECHANISM OF BIGEMINAL RHYTHM INDUCED BY ITS TOXIC DOSAGE STUDIED BY THE CHANGE OF THE TRANSMEMBRANE ACTION POTENTIAL
- EFFECTS OF GLUCAGON, PROSTAGLANDIN E_1 AND DIBUTYRYL CYCLIC 3',5'-AMP UPON THE TRANSMEMBRANE ACTION POTENTIAL OF GUINEA PIG VENTRICULAR FIBER AND MYOCARDIAL CONTRACTILE FORCE
- Cardiovascular Responses to Intravenous Isoproterenol Infusion in Subjects with and without Left Ventricular Hypertrophy
- A Study of Metastatic Tumors to the Heart, Pericardium and Great Vessels : I. Incidences of Metastases to the Heart, Pericardium and Great Vessels
- Pharmacokinetics of Low Dose Etoposide after Multiple Oral Administration.