Study on the Idiopathic Cardiomyopathy Diagnostic Value of the Apexcardiogram, ^<131>Cs Scintiscanning of the Heart and Plasma Hydroxyproline

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Seventy cases of ICM including 8 HOCM, 20 familiar cardiomyopathies and 3 heart diseases with collagen disease were examined by ACG, Scintigram of the heart using ^<131>Cs and the measurement of the plasma hydroxyproline containing collagen-like protein comparing with coronary heart disease. The results were evaluated as a useful technique for the diagnosis of ICM. 1. Prominent "a" wave and bulging in ACG is observed in ICM frequently and its utility as a routine test was emphasized, especially with pharmacological test with amyl nitrite for the mild case, and with nitroglycerin for the differential diagnosis to the coronary heart disease, be-cause nitroglycerin improves ACG findings in coronary heart disease while not in ICM. 2. On ICM scintigram of the heart showed sparse defect and low uptake of ^<131>Cs into the heart which is reported as an uptake index in this study. 3. Some of the cases of ICM including old case showed high level of plasma hydroxyproline containing collagen-like protein over 8.0μg/ml such as seen in fresh myocardial infarction, while normal value was less than 7.0μg/ml in this study. The elevated level of plasma HOP suggests the active process of the fibrosis in the heart of ICM and of continuous fibroplastic mechanism in the heart of ICM was discussed.
社団法人日本循環器学会の論文