狭心痛の発現機序 : 心臓交感神経求心性線維の興奮動態

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Because of nonspecific irritability of the sensory endings which are considered to be signalling the noxious events in the heart, the generation mechanisms for anginal pain have not clearly been elucidated. In the present studies, the left ventricular sympathetic afferents which elicite the pseudoaffective responses were determined, and their mode of excitation during myocardial ischemic products were investigated. Methods: 1. Opetative Procedures Investigations were carried out on mongrel dogs (17 to 25 kg) anesthetized with sodium pentobarbital (25 to 35 mg/kg, i.v.). The thoracic cavity was opened by resecting the first to 8th ribs of the left side. After pericardiotomy, the anterior descending branch of the left coronary artery proximal to its origin was carefully freed from the surroundings not to damage the nerves which run close to it. Then, a screw clamp and a probe of the magnetic-flowmeter were set on it. A straingauge bridge (force displacement or length displacement) was sewn onto the anterior wall nourished by the anterior branch. Thereafter, a pair of the cross-thermocouples (constant current heating) were sewn into the interior of the wall to measure the blood flow in the myocardium. The surface electrocardiogram was recorded by a monopolar electrode fixed on to the catheter inserted into the right femoral artery and to the needle inserted into the left ventricular cavity through the apical dimple. 2. Nerve Preparation After transsecting the cervical vagosympathetic trunks, the left middle cardiac nerve proximal to its origin and a nerve bundle projecting onto the anterior aspect of the left ventricle were freed from the surrounding connective tissues to set them across the stimulating electrodes (S_1 and S_2 in Fig. 1) The left thoracic sympathetic trunk and its third communicating ramus were also freed. Thereafter, the ramus was cut off from the spinal cord and was dissected into fine filaments. One of the filaments was then set across the measuring electrodes (M in Fig. 1). All the preparations were covered at all time with liquid paraffin at 37℃.
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狭心痛の発現機序 : 心臓交感神経求心性線維の興奮動態

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