4. On the Role of Renin-Angiotensin System with Special Relation to Aldosterone for the Etiology of Hypertension

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From our animal experiments and clinical experiences the conclusion will be as follows. ( 1 ) The increase of both renin activities and aldosterone excretion is parallely recognized in acute stadium of hypertension of GOLDBLATT'S rats. However the etiological role of both factors to hypertension is not yet clear. ( 2 ) We must say that the pressor mechanism of renal vascular hypertension in man is still also obscure. (3) We can not recognize the role of renin-angiotensin system and aldosterone as the etiology of essential hypertension. We suppose that hypersecretion of both factors is merely the secondary phenomenon. (4) Both factors are increased in secondary aldosteronism. It is still obscure why they don't cause hypertension. In conclusion the essential role of renin-angiotensin system is still not clear, but they certainly work as the electrolytes regulator (especially sodium and potassium) to renal tubules dirrectly or by means of aldosterone secretion. According to our experiments, it seems that aldosterone excretion depend entirely on the dynamics of renin-angiotensin system so far.
社団法人日本循環器学会の論文
1966-02-20