Hyperlipoproteinemia as a Risk Factor for Ischemic Heart Disease : 53th Annual Scientific Session of the Japanese Circulation Society

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概要

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• We analyzed serum lipoproteins and apolipoprotein E (apo E) from 199 patients in CCU, having ischemic heart disease. and from 211 healthy subjects. It was suggested that serum lipoprotein abnormalities, especially elevated low density lipoprotein (LDL) levels, are closely related to atherogenesis in relatively young patients and subjects with severe coronary lesions. The frequency of apo E-4 was higher and that of E-2 was lower in the CCU group than in the control group. Apo E mutants. E-7 (Glu_<244>→Lys, Glu_<245>Lys) and E-5 (Glu_3→<245>Lys), were also frequent in the CCU group. Apo E isoproteins have higher pI in the order E-2, E-3. E-4, and we observed that LDL-cholesterol levels in-creased in the same order. The apo E mutants. E-5 and E-7, are also more basic than E-4. These findings suggest that basic apo Es were associated with the development of atherosclerosis. The prevalence of familial hypercholesterolemia (FH) in the CCU group was more than 10 times higher than the reported frequency of FH heterozygotes in normal population. The persistence of marked hypercholesterolemia from infancy probably makes FH patients susceptible to atherosclerosis. Based on the analysis of LDL-receptor protein synthesis, various types of mutations were observed even in phenotypically homozygous FH patients. FH homozygotes were divided into 2 groups, a receptor-negative group and a receptor-defective group. We found a great difference in the frequency of coronary heart disease depending on whether even a small number of receptors were present or not.

• 社団法人日本循環器学会の論文
• 1990-04-20

著者

• YAMAMOTO Akira

  National Cardiovascular Center

• HIRAMORI KATSUHIKO

  National Cardiovascular Center; Department of Internal Medicine

• HAZE KAZUO

  National Cardiovascular Center; Department of Internal Medicine

• Haze Kazuo

  Department Of Medicine National Cardiovascular Center

• Yamamura Taku

  National Cardiovascular Center

• Yamamura Taku

  Department Of Etiology Research Institute Of National Cardiovascular Center:the Group Of The Researc

• Yamamura Taku

  Metabolism National Cardiovascular Center

• Yamamura Taku

  Research Institute National Cardiovascular Center

• Haze Kazuo

  National Cardiovascular Center

• Hiramori Katsuhiko

  Department Of Medicine National Cardiovascular Center

• Miyake Yasuko

  Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute

• TAJIMA SHOJI

  National Cardiovascular Center Research Institute

• MIYAKE YASUKO

  National Cardiovascular Center Research Institute

• NOMURA SHUICHI

  National Cardiovascular Center Research Institute

• NOMURA Shuichi

  Research Institute National Cardiovascular Center

• Hiramori Katsuhiko

  National Cardiovascular Center

• Miyake Yasuko

  Department Of Etiology And Pathophysiology National Cardiovascular Center Research Institute

• Yamamura Taku

  Department Of Etiology Research Institute Of National Cardiovascular Center:the Group Of The Researc

• Yamamoto Akira

  Health Care Facilities For Aged Mino-o Life Plaza

• Yamamoto Akira

  Department Of Etiology And Pathophysiology National Cardiovascular Center Research Institute

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