EFFECTS OF ISOPROTERENOL ON THE DEVELOPING HEART IN RATS : 51st Annual Meeting of the Japanese Circulation Society
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概要
- 論文の詳細を見る
Many clinical clues suggest a link between abnormal catecholamine function during a phase of rapid cardiac development and hypertrophic cardiomyopathy. However, experimental investigation focusing on abnormal catecholamine function during the fetal period as the pathogenesis of hypertrophic cardiomyopathy has not yet been carried out. In this study. isoproterenol (ISO) was administered to pregnant female rats and the effects of the drug on the hearts of their offspring were studied morphologically. Fifty /μg/kg/day of ISO was administered subcutaneously to 15 pregnant female rats 5 days a week for 3 weeks and the offspring were killed at 2 days, 4 weeks or 7 weeks after birth. Isotonic saline was administered to 15 pregnant female rats as control. The hearts of the offspring were removed and weighed immediately. The ventricles were cut in two, parallel to the atrio-ventricular groove. Left and right ventricular free wall thickness and interventricular septal thickness were measured. Under light-microscope, myocardial fiber diameter was measured and myocardial fiber disarray was assessed. Fine structural alterations of the cardiac muscle cells were observed by an electron microscope. The hearts of newborn offspring from pregnant rats treated with ISO showed disproportionate septal hypertrophy and frequent inter- and intracellular disarray in the interventricular septum. However, these changes were not prominent at 7 weeks after birth. These results suggest that abnormal catecholamine function during the fetal period may result in disproportionate septal hypertrophy.
- 社団法人日本循環器学会の論文
- 1990-01-20
著者
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SUZUKI tadashi
The Second Department of Internal Medicine,Gunma University School of MedicineThe Second Department
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Iwasaki Tsutomu
Second Department Of Internal Medicine Gunma University School Of Medicine
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Iwasaki Tsutomu
The Second Department of Internal Medicine, Gunma University School of Medicine
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Takino Yutaka
The Second Department of Internal Medicine, Gunma University School of Medicine
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Iwasaki Tsutomu
The Second Department Of Internal Medicine Gunma University School Of Medicine
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Suzuki Tadashi
The Second Department Of Internal Medicine Gunma University School Of Medicine
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Takino Yutaka
The Second Department Of Internal Medicine Gunma University School Of Medicine
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Imanari Tetsuro
The Second Department Of Internal Medicine And The Department Of Hygiene Gunma University School Of
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Iwasaki Tsutomu
The Second Department Of Internal Medicine
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Imanari Tetsuro
Second Department Of Internal Medicine Gunma University School Of Medicine
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