THE LONG-TERM HEMODYNAMIC EFFECT OF FUSARIC ACID IN ELDERLY HYPERTENSIVE PATIENTS

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概要

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• The hemodynamic effect of fusaric acid calcium salt (calcium salt of 5-butylpicolinic acid), an inhibitor of dopamine β-hydroxylase, was studied in long-term administration of this agent in 10 elderly hypertensice patients. The hemodynamic items were measured by dye-dilution method before and 3 months, 6 months and one year after administration of fusaric acid calcium salt. The main hemodynamic changes observed were as follows: 1) Heart rate did not show any consistent change. 2) Systolic, diastolic and mean blood pressure decreased. The mean values of these pressures after fusaric acid calcium salt administration were significantly lower than the mean values before administration of this agent. 3) Total peripheral vascular resistance index decreased. The mean values of this index at 3 months, 6 months and one year after fusaric acid calcium salt administration were significantly lower than the mean value before administration of this agent. 4) Cardiac index showed various changes throughout administration of fusaric acid calcium salt. The changes in this index might be secondary following the changes in total peripheral vascular resistance index, an inverse correlation being existed between them. 5) Stroke volume index showed almost a similar pattern of change as observed in cardiac index. An inhibitory action of fusaric acid calcium salt on the inotropism of the heart could be hardly found. 6) Plasma volume showed no tangible changes after fusaric acid calcium salt administration throughout one year. It might be concluded that fusaric acid calcium salt elicited the hypotensive response primarily through the reduction of total peripheral vascular resistance index.

• 社団法人日本循環器学会の論文
• 1976-10-20

著者

• TERASAWA FUJIO

  The 3rd Department of Internal Medicine, Faculty of Medicine, University of Tokyo and the Yokugukai

• Hon Ying

  The Yokufukai Geriatric Hospital

• Suzuki Takaomi

  The Yokufukai Geriatric Hospital

• Takaomi Suzuki

  The Yokufukai Geriatric Hospital

• Terasawa Fujio

  The 3rd Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• Ying Lie

  The Yokufukai Geriatric Hospital

関連論文

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• Pressoreflex Arising from the Left Coronary Artery
• URINARY NOREPINEPHRINE EXCRETION IN ELDERLY HYPERTENSIVE PATIENTS DURING ADMINISTRATION OF FUSARIC ACID
• THE LONG-TERM HEMODYNAMIC EFFECT OF FUSARIC ACID IN ELDERLY HYPERTENSIVE PATIENTS
• THE HYPOTENSIVE EFFECT OF FUSARIC ACID : THE RESULTS OF LONG-TERM ADMINISTRATION OF FUSARIC ACID IN ELDERLY HYPERTENSIVE PATIENTS
• TIME0URSE CHANGES IN BLOOD PRESSURE, URINARY EXCRETION OF NOREPINEPHRINE AND DOPAMINE AFTER ADMINISTRATION OF FUSARIC ACID IN A SINGLE DOSE IN ELDERLY HYPERTENSIVE PATIENTS

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