POSSIBLE EXISTENCE OF PRORENIN IN RABBIT RENAL CORTEX

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概要

• 論文の詳細を見る

• The possible existence of prorenin (inactive form of renin) in rabbit renal cortex was studied. Renal cortex was homogenized with 0.25 M sucrose. Following centrifugation at 800 g for 10 mm, the supernatant (Fraction H) was centrifuged at 20,000 g for 20 min. The pellet (Fraction G) was separated from soluble fraction (Fraction S). Intravenous injection of non-treated Fraction G caused a little blood pressure elevation in rats. However, the pressor activity of the same amount of Fraction G which was frozen and thawed 5 times previously was more than 10 times as that of non-treated one. The renin activity in preincubated fraction G with Fraction S was 2-fold the summation of the activity of renin in each fraction, when measured using indirect method. Fraction S lost not only the renin activity but also the renin activating activity when heated for 5 min at 100℃. Exposure to pH 3.5 made no influence on renin activity in either Fraction G and S.

• 社団法人日本循環器学会の論文
• 1976-03-20

著者

• Hiwada Kunio

  The 2nd Department Of Internal Medicine Ehime University School Of Medicine

• Kokubu Tatsuo

  2nd Department of Internal Medicine, Ehime University School of Medicine

• Hiwada Kunio

  2nd Department of Internal Medicine, Ehime University School of Medicine

• Hiwada Kunio

  2nd Department Of Internal Medicine Ehime University School Of Medicine

• Kokubu Tatsuo

  2nd Department Of Internal Medicine Ehime University School Of Medicine

• Yamamura Yuichi

  President of Osaka University

• Yamamura Yuichi

  3rd Dept. of Med., Osaka Univ. Med. School

• Yamamura Yuichi

  3rd Department Of Internal Medicine Osaka University School Of Medicine

• Kokubu Tatsuo

  3rd Dept. Of Intern. Med.. Osaka Univ. Med. School.

• Yamamura Yuichi

  3rd Dept. Of Intern. Med.. Osaka Univ. Med. School.

• Yamamura Yuichi

  The 3rd Department Of Medicine Osaka University School Of Medicine

• Yamamura Yuichi

  The Third Dept. Of Med. Osaka Univ. School Of Med.

• Kokubu Tatsijo

  3rd Dept. Of Intern. Med.. Osaka Univ. Med. School.

• Yamamura Yuichi

  3rd Dept. Of Med. Osaka Univ. Med. School

• Yamamura Yuichi

  Third Department Of Medicine Osaka University Hospital

• Kokubu Tatsuo

  The Department Of Internal Medicine Kinki Contral Hospital

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