動脈硬化症に関する研究 (第1報) : 健康人, 冠疾患, 糖尿病, 脳卒中, 高血圧例の血清脂質値について
スポンサーリンク
概要
- 論文の詳細を見る
Various investigations have been per- formed about the pathogenesis of atherosclerosis, and the view has recently become dominant that the disease is caused by disturbance of lipid metabolism. The author studied the serum lipid values of normal subjects of various ages and then of subjects with coronary diseases, diabetes, cerebrovascular diseases and hypertension. Each of the individuals was tested, as far as possible for all the items, cholesterol, lipoprotein index, free fatty acid, total fatty acid, neutral fat and phospholipid, and an attempt was made to determine which of them might serve as the best pointers of atherosclerosis. Experimental Methods The subjects consisted of 106 normotensive persons those whose blood pressure was consistently below 140/90 mmHg by repeated measurement--32 cases of diabetes mellitus. 22 of angina pectoris, 30 of myocardial infarction, 30 of cerebrovascular lesions and 101 of hypertension. The measurement of serum lipid fractions was carried out by the methods show below. 1) Cholesterol : Costello's method. 2) Lipoprotein index : paper electrophoresis. 3) Total fatty acid : extraction by Bloor and Katsura-Hatakeyama's method and measurement by alkali titration. S) Neutral fat : extraction by the same method and measurement by Bragdon's method. 6) Phospholipid : modified Zilversmit's method. Results 1) Serum lipid levels of normotensive subjects. In normotensive subjects under 50 years, the serum total cholesterol level was 167±35 mg/dl, free cholesterol level 52±15 mg/dl, average lipoprotein index 2.9±1.2, nonesterified fatty acid 0.25±0.12 mEq/l, serum total fatty acid level 268± mEq/l, serum neutral fat level 187±50 mg/dl, serum phospholipid level 155±36 mg/dl, and serum CIP ratio 0.97±0.26 ; and those levels above 50 years 185±40 mg/dl (total cholesterol), 59±15 mg/dl (free cholesterol), 3.5±1.9 (lipoprotein index), 0.32±0.10 mEq/l (nonesterified fatty acid), 376±85 mg/dl (total fatty acid). 224±80 mg/dl (neutral fat), 186±81 mg/dl (phospholipid), 1.13±0.35 (C/P ratio). Between the two age groups of normotensive subjects there is statistically significant difference in the total cholesterol, free cholesterol and phospholipid. The lipoprotein index, phospholipid, neutral fat, free fatty acid and total fatty acid have a tendency to increase with age. But there were two or three of the serum lipid fractions which showed a tendency of decreasing after 70 years of age.
- 社団法人日本循環器学会の論文
- 1961-07-15
著者
関連論文
- 動脈硬化症に関する研究 : 硬化発現に対する血中各脂質分劃の意義について : 第16回日本循環器学会関東甲信越地方学会総会
- 32) ヘパリン舌下錠及びトローチの血中脂質, 血液凝固に及ぼす影響について(第13回日本循環器学会関東・甲信越地方学会総会)
- 33)降コレステロール剤に関する研究 : 特にリノール酸について(第12回日本循環器学会関東地方会総会)
- 32)動脈硬化症に関する研究 : ヘパリンとアルギン酸硫酸エステルの清浄能について(第12回日本循環器学会関東地方会総会)
- 33) 動脈硬化症に関する研究 : ACTH及び副腎皮質ホルモンと血中脂質との関係(第11回日本循環器学会関東地方学会総会)
- 64) 動脈硬化症に関する研究 : 大動脈壁における脂質処理機構を中心として(第24回 日本循環器学会総会)
- 18) 動脈硬化症に關する研究 : 副腎ホルモンと脂質代謝異常面からの考察(第23回日本循環器學會總會)
- 動脈硬化症に関する研究 (第2報) : 高血圧例の血清脂質値について
- 動脈硬化症に関する研究 (第1報) : 健康人, 冠疾患, 糖尿病, 脳卒中, 高血圧例の血清脂質値について