EFFECTS OF LEUKOTRIENE D_4 0N MYOCARDIAL BLOOD FLOW AND HIGH ENERGY PHOSPHATE CONCENTRATION IN ANESTHETIZIED DOGS

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The effects of intracoronary administration of leukotriene D_4 (LTD_4) on myocardial blood flow (MBF) and myocardial energy metabolism in anesthetized open-chest dogs were examined, and compared with those of coronary ligation. Two series of experiments were conducted. In the first, LTD_4 (0-3.0μg/kg) was injected into the left anterior descending coronary artery (LAD) and MBF was measured. While no changes in MBF were observed after 0.5 μg/kg of LTD_4, a significant decrease in MBF in the LAD area was apparent after 1.0 μg/kg of LTD_4, with a return to baseline values by within 10 min after the injection. With 3.0 μg/kg of LTD_4, MBF remained decreased up to 15 min after the injection. In the second study, myocardial high energy phosphate concentrations in the LAD area were determined 5 min after LTD_4 administration and compared to those after ligation. ATP levels in the 1.0-3.0 μg/kg LTD_4 groups were significantly less than those in the ligation group, although there were no associated significant differences in MBF values in the LAD area. These results indicate that LTD_4 brings about changes in myocardial energy metabolism which are not secondary to reduced blood flow.
社団法人日本循環器学会の論文
1994-09-20