Limitations of Compensation by Endogenous Atrial Natriuretic Peptide in Heart Failure : COMPENSATORY MECHANISMS AND THEIR LIMITATIONS IN HEART FAILURE
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the role of endogenous atrial natriuretic peptide (ANP) in patients with congestive heart failure (CHF), the relationship between plasma ANP and cyclic guanosine monophosphate (cGMP) levels and the prognosis of patients with CHF was examined. In patients with chronic mild to moderate CHF, there was a positive correlation between plasma ANP and cGMP levels (r=0.81, p<0.001). However, there was no significant correlation between these plasma levels in patients with chronic severe CHF, in whom the cGMP concentration reached a plateau in spite of high levels of ANP. The ANP extraction level and the cGMP production level in the pulmonary and systemic circulation correlated significantly in patients with mild CHF. In contrast, there was no significant correlation between the 2 parameters in patients with severe CHF, and the molar ratios of cGMP production to ANP extraction in the pulmonary and systemic circulation were significantly lower than those in patients with mild CHF. In 44 patients with chronic severe CHF who were followed up over 2 years, plasma ANP levels provided more sensitive and specific prognostic information than any other parameters. These results indicate that ANP receptors coupled to guanylate cyclase may be down-regulated in patients with chronic severe CHF, suggesting that high plasma ANP levels as a prognostic predictor may be associated with limitations of compensation by endogenous ANP.
- 社団法人日本循環器学会の論文
- 1992-05-20
著者
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Wada Atsuyuki
The First Department of Internal Medicine, Shiga University of Medical Science
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Tsutamoto Takayoshi
The First Department of Internal Medicine, Shiga University of Medical Science
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KlNOSHITA MASAHIKO
The First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
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Kanamori Toshiyuki
The First Department Of Internal Medicine Shiga University Of Medical Science
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Tsutamoto Takayoshi
The First Department Of Internal Medicine Shiga University Of Medical Science
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Klnoshita Masahiko
The First Department Of Internal Medicine Shiga University Of Medical Science
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Wada Atsuyuki
The First Department Of Internal Medicine Shiga University Of Medical Science
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Miyauchi Nobuo
The First Department Of Internal Medicine Shiga University Of Medical Science
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MURATA TAKAKO
The First Department of Internal Medicine Shiga University of Medical Science
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