STUDIES ON THE CARDIAC SARCOPLASMIC RETICULUM IN MYOCARDIAL INFARCTION
スポンサーリンク
概要
- 論文の詳細を見る
1. Influence of ischemia on the biochemical properties of the sarcoplasmic reticulum (SR) was studied in the experimental myocardial infarction in the dog. 2. Ca^<2+>-uptake rate of SR decreased at around 90 minutes after coronary occlusion. This reduction was roughly in parallel with the reduction in the Ca^<2+>-Mg^<2+>-stimulated ATPase activity. However, Ca^<2+>-binding rate of SR was kept within the range of that of the non-infarcted tissue through the time course of myocardial infarction. 3. Ca^<2+>-Mg^<2+>-stimulated ATPase activity decreased at around 3 hours after coronary occlusion to about 50% of that of the non-infarcted portion. 4. In SDS gel electrophoresis, the protein band with the largest molecular weight amount three major components decreased at 3 hours after coronary occlusion, which is suggestive of ATPase. At 48 hours after coronary occlusion, the protein with the smallest molecular weight in the major proteins also decreased. 5. Ca^<2+>-uptake rate, Ca^<2+>-Mg^<2+>-stimulated ATPase activity and the substructural changes returned to the normal level and pattern at around 28 days after coronary occlusion.
- 社団法人日本循環器学会の論文
- 1978-05-20
著者
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Takeyama Y
Division Of Cardiology Department Of Internal Medicine Showa University Fujigaoka Hospital
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Takeda Ken
The Third Department Of Internal Medicine And The Department Of Biochemistry Showa University School
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Takeyama Youichi
Division Of Cardiology Showa University Fujigaoka Hospital
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Takeyama Youichi
The 3rd Department Of Internal Medicine Showa Univ. School Of Medicine
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Toba Kenji
The 3rd Department Of Internal Medicine Showa Univ. School Of Medicine
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TOBA KENJI
"The 3rd Department of Internal Medicine,Showa Univ. School of Medicine
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KATAGIRI TAKASHI
The 3rd Department of Internal Medicine,Showa Univ. School of Medicine
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Katagiri Takashi
The 3rd Department Of Internal Medicine Showa University School Of Medicine
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Tashiro Kouji
The Second Department Of Pathology Showa University School Of Medicine
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Kimura Tomomi
Department Of Biochemistry Showa University School Of Medicine
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Takeyama Youichi
Third Department Of Internal Medicine And Second Department Of Pathology
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