AN ALTERED DISTRIBUTION AND ELIMINATION OF DIGOXIN IN ANEMIC PATIENTS AND EXPERIMENTALLY INDUCED ANEMIC RATS
スポンサーリンク
概要
- 論文の詳細を見る
Digoxin was administered orally to eight anemic patients in their anemic and convalescent stages, and serum digoxin concentration was determined by radioimmunoassay. In the anemic patients a significantly lower level of serum digoxin concentration was observed in anemic state compared with convalescent stage at 72 hours after the drug administration (p<0.01). In usual clinical use, a full digoxin effect is expected to be attained as 72 hours. Tritiated digoxin was administered intravenously to anemic and control rats and the tritium in samples of the blood, myocardium and urine were counted in a liquid scintillation counter. The anemic rats showed significantly lower level of serum ^3H-digoxin at 6 hours (p<0.01) and lower myocardial concentration at 24 hours (p<0.01). Larger amount of urinary excretion of ^3H-digoxin was observed in the anemic rats 6 hours after the drug administration. No significant difference in fecal excretion of ^3H-digoxin was found between the anemic and control rats.
- 社団法人日本循環器学会の論文
- 1984-11-20
著者
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Kitamura Kazuo
Department Of Internal Medicine Circulatory And Body Fluid Regulation University Of Miyazaki
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Takeda H
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Bamba M
Ika Public Hospital
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HAMAMOTO HAJIME
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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KITAMURA KAZUTO
Department of Laboratory Medicine, Kyoto Prefectural University of Medicine
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TAKEDA HARUHIKO
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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BAMBA MICHIO
Ika Public Hospital
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TAKANASHI TADAHIRO
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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TAKINO TATSURO
Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
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Takino Tatsuro
3rd Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Takanashi T
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Kitamura Kazuto
Department Of Laboratory Medicine Kyoto Prefectural University Of Medicine
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