Human Atrial Natriuretic Peptide Infusion for a Neonate With Congestive Heart Failure After Total Correction of Total Anomalous Pulmonary Venous Connection

概要

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A successful casc of human atrial natriuretic peptide (HANP) infusion therapy for a neonate who developed congestive heart failure (CHF) after total repair of total anomalous pulmonary venous connection was performed on the first day of life. Following 14h of HANP infusion at incremental doses of 0.125-0.25μg.kg^<-1>・min^<-1>, urine output and hemodynamics dramatically improved. Urine output increased from 1.1 to 10.6 ml/h (p<0.0001) and good urinary output (13.0ml/h) was maintained even after discontinuation of the infusion. During the infusion, the heart rate decreased from 166 to 152 beats/min (p<0.0001, and the systemic systolic blood pressure increased from 82 to 103mmHg (p<0.0001). Central venous pressure was not significantly affected by HANP infusion. This is the first successful case of HANP infusion therapy as the first treatment of post-operative pulmonary hypertension in this age group. This therapy can be used safety and may be userul in neonates with CHF resulting from other causcs, but more investigation is needed.
社団法人日本循環器学会の論文
2000-08-20