Standardized Ejection Fraction as a Parameter of Overall Ventricular Pump Function

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概要

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• To evaluate the pump function of the ventricle, a parameter which (i) incorporates sustolic and diastolic function and (ii) separates the heart from preload and afterload is needed. This study utilized ejection fraction (EF), calculated from the end-systolic (ES) and end-diastolic (ED) pressure-volume relationship (PVR) using an arbitrary set of loading conditions. Ten isolated canine hearts with a balloon placed inside the left ventricle were used to determine the ESPVR and EDPVR. An end-diastolic volume (EDV) at a pressure of 15 mmHg and an end-systolic volume (ESV) at 70 mmHg were obtained from the EDPVR and ESPVR, respectively. EF was calculated as (EDV-ESV)/EDV. With low-dose (8μg/min) and high-dose (40μg/min) dobutamine infusion, the EF increased from 0.25±0.16 to 0.33±0.13 and 0.57±0.08 (p<0.01), respectively, in conjunction with increases in end-systolic elastance from 3.11±0.83 to 3.48±1.08 and 5.38±1.91 mmHg/ml (p<0.01). It was thus concluded that because the estimation of EF separates the heart from preload and afterload, this method may facilitate comparing overall pump function of hearts beating under different loading conditions.

• 社団法人日本循環器学会の論文
• 2000-06-20

著者

• Kawai Akihiko

  Department Of Cardiovascular Surgery The Heart Institute Of Japan Tokyo Women's Medical Univers

• Kormos Robert

  University Of Pittsburgh Medical Center

• Kormos Robert

  Division Of Cardiothoracic Surgery

• MORITA Shigeki

  Division of Cardiovascular Surgery, Faculty of Medicine, Kyushu University

• Griffith Bartley

  University Of Pittsburgh Medical Center

• Griffith Bartley

  Division Of Cardiac Surgery University Of Maryland School Of Medicine And Va Medical Center At Balti

• Astbury Jeffrey

  Shadyside Hospital

• Shaub Richard

  Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of Pittsbu

• Kawai Akihiko

  Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of Pittsbu

• Morita Shigeki

  Division Of Cardiothoracic Surgery Department Of Surgery School Of Medicine University Of Pittsburgh

• Shaub Richard

  Division Of Cardiothoracic Surgery Department Of Surgery School Of Medicine University Of Pittsburgh

• Kada Akiko

  Department Of Clinical Research And Development National Cardiovascular Center

• Kawai Akihiko

  Department Of Cardiovascular Surgery The Heart Institute Of Japan Tokyo Women's Medical Univers

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