The Stress-Strain Relationship of the Diastolic Cardiac Muscle and left Ventricular Compliance in the Pressure-Overload Canine Heart : SYMPOSIUM ON HEART MECHANICS IN DIASTOLE

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The relation between left ventricular (LV) compliance, chamber geometry and LV muscle compliance in pressure-overload hearts was studied. The diastolic pressure (P)-volume (V) relationship was evaluated at different ventricular volumes of isovolumic beat in 4 pressure-overload hypertrophied (H) and 5 normal (N) hearts. In H, the ratio of the LV volume at the EDP of 15 mmHg to LV weight (LVW) was 0.34 ± 0.08 (SD) ml/g (N: 0.63 ± 0.07, p < 0.01). Thus the occurrence of concentric hypertrophy due to pressure-overload was confirmed. The P-V relation was expressed as, ΔV = a - b・exp (-cP), where a, b and c were constants, ΔV = V - V_0, and V_0 was the initial volume at EDP = 0 cmH_2O. Since this equation leads to the relation: dΔV/ dP = c (a - ΔV), c may be regarded as a parameter which represents the LV chamber compliance. In H, c was 0.074 ± 0.024 (SD) mmHg^<-1> (N: 0.109 ± 0.008 mmHg^<-1> , p < 0.01). Therefore, H was found to show decrease of LV compliance. The biaxial stress (σ)-strain () relation was derived from the P-V relation based on large deformation theory. The - relationships of myocardium in H were not apparently different from that in N. However, there was a close correlation between c and LV volume (at EDP = 15 mmHg)/ LVW (r = 0.83). Thus it was found that the change in LV compliance in H resulted from the change in LV chamber geometry.
社団法人日本循環器学会の論文
1982-01-20