Effects of Aprindine on Electrophysiological Properties of the Atrial Muscle in Man
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概要
- 論文の詳細を見る
The effects of aprindine on atrial vulnerability were studied in ll patients; 9 with paroxysmal atrial fibrillation (PAF), and 2 with Wolff-Parkinson-White syndrome, aged 19 to 69 (55.9±16.5; mean±SD). Before and 10 min after the intravenous injection of aprindine (1.5 mg/kg), programmed extrastimulation was performed from the right atrial appendage. Atrial vulnerability was assessed by evaluating the repetitive atrial firing zone (RAFZ), conduction delay zone (CDZ), maximum conduction delay (Max.CD) and fragmented atrial activity zone (FAAZ). After the injection, the duration of the P wave and QTc interval was significantly prolonged without any change in blood pressure or heart rate. RAF was observed in 8 patients under control conditions. However, after the injection of aprindine, the RAFZ completely disappeared in 2 patients, was narrowed in 4, and became wider in 1. AF was induced in the remaining patient. The zone significantly reduced (p<0.01) without any change in CDZ or Max.CD. While FAA was observed in 5 patients under control conditions, it completely disappeared in 2 patients, was narrowed in 1, and did not change in the remaining 7 after the injection of aprindine. In patients whose RAFZ narrowed after administration of aprindine, the wavelength, as determined from the atrial effective refractory period and conduction velocity, was augmented. These results indicate that aprindine suppresses atrial vulnerability with an augmentation of the wavelength. However aprindine exaggerated atrial vulnerability in some patients, such that atrial fibrillation was induced.
- 社団法人日本循環器学会の論文
- 1995-05-20
著者
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Shimizu Akihiko
Faculty Of Health Science Yamaguchi University School Of Medicine
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Yano Katsusuke
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome
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Hayano Motonobu
Third Department Of Internal Medicine Nagasaki University
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Hayano Motonobu
The Third Department of Internal Medicine, Nagasaki University School of Medicine
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Yano Katsusuke
The Third Department of Internal Medicine, Nagasaki University School of Medicine
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Isomoto Shojiro
The Third Department of Internal Medicine, Nagasaki University School of Medicine
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Hirata Tetsuya
Third Department of Internal Medicine, Nagasaki University, School of Medicine
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Centurion Osmar
The Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Shimizu Akihiko
The Third Department Of Internal Medicine Nagasaki University School Of Medicine
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KONOE ATSUSHI
The Third Department of Internal Medicine, Nagasaki University School of Medicine
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Konoe Atsushi
The Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Yano Katsusuke
The Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Hirata Tetsuya
Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Hirata Tetsuya
The 3rd Department Of Internal Medicine Nagasaki University School Of Medicine
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Hirata Tetsuya
The Third Department of Internal Medicine Nagasaki University School of Medicine
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Hano Osamu
The Third Department of Internal Medicine, Nagasaki University School of Medicine
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KAIBARA MUNESHIGE
The Third Department of Internal Medicine, Nagasaki University School of Medicine
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Isomoto Shojiro
Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Yano Katsusuke
The Third Department Of Internal Medicine
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Isomoto Shojiro
Department Of Cardiovascular Medicine Nagasaki University School Of Medicine
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Isomoto Shoujiro
Department Of Cardiovascular Medicine Nagasaki University School Of Medicine
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Isomoto Shojiro
Department Of Cardiovascular Medicine Graduate School Of Biomedical Sciences Nagasaki University
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Hano Osamu
Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Konoe Atsushi
Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Yano Katsusuke
Division Of Cardiovascular Medicine School Of Biomedical Sciences Nagasaki University
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Kaibara Muneshige
Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Isomoto Shoujiro
The Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Hayano Motonobu
The 3rd Department Of Internal Medicine Nagasaki University School Of Medicine
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Kaibara Muneshige
The Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Hano Osamu
The Third Department Of Internal Medicine Nagasaki University School Of Medicine
-
Hayano Motonobu
Third Department Of Internal Medicine Nagasaki University School Of Medicine
-
Centurion Osmar
Third Department Of Internal Medicine Nagasaki University School Of Medicine
-
Yano Katsusuke
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biome
-
Hayano Motonobu
The Third Department Of Internal Medicine Nagasaki University School Of Medicine
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Isomoto Shojiro
Department Of Cardiovascular Medicine Course Of Medical And Dental Sciences Graduate School Of Biomedical Sciences Nagasaki University
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