Sympathetic Hyperactivity in Patients With Vasospastic Angina : Assessment by Spectral Analysis of Heart Rate and Arterial Pressure Variabilities
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概要
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The autonomic nervous system may play an important role in regulating coronary arterial tone. To evaluate the role of autonomic nervous activity in patients with vasospastic angina (VSA), we studied 10 VSA patients with patent coronary artery (mean ; 56 yr, range ; 44-66 yr) and 8 normal subjects (mean ; 58 yr, range ; 35-71 yr). ECG and arterial pressure were continuously recorded for 4 min in a supine position at 7:30 am, 10:30 am, and 4:30 pm. Low-frequency (LF ; 0.04-0.15 Hz) and high-frequency (HF ; 0.20 Hz) components of the beat-to-beat variabilities of the R-R interval (RRI) and systolic arterial pressure (SAP) were then estimated by autoregressive power spectral analysis. The LF-Normalized Power (LF-NP ; [LF Power]/[Total Power]-[Direct Current Power]) of both the RRI and SAP variabilities were greater in VSA patients than in normal subjects (RRI : 0.51±0.07, 0.51±0.07, 0.53±0.06, vs 0.25±0.04, 0.31±0.05, 0.31±0.06, at 7:30 am, 10:30 am, and 4:30 pm respectively : p=0.010, 0.044, 0.018. SAP : 0.62±0.06, 0.53±0.06, 0.57±0.06 vs 0.37±0.04, 0.30±0.06, 0.26±0.07, respectively : p=0.006, 0.017, 0.003.). The LF-power of SAP variability also tended to be greater in VSA patients. There was no difference in the HF-component coefficient of variance (CCV(%)=100×(component power)^<1/2>/mean RR intervals) of the RRI variabilities between the 2 groups. These results indicate that increased sympathetic vasomotor tone and cardiac sympathetic predominance may play an important role in patients with VSA.
- 1995-12-20
著者
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CHIKAMORI Taishiro
Department of Cardiology, Tokyo Medical University
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Sato Takayuki
Department of Cardiovascular Control, Kochi Medical School
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YAMASAKI Fumiyasu
Department of Clinical Laboratory, Kochi Medical School Hospital
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Yamasaki Fumiyasu
Department Of Clinical Laboratory Kochi Medical School
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Yamasaki Fumiyasu
Deparment Of Clinical Laboratory Kochi Medical School
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Doi Yoshinori
Department Of Medicine And Geriatrics Kochi Medical School
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Doi Yoshinori
Department Of Gastroenterology Otemae Hospital
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Chikamori Taishiro
Department Of Cardiology Tokyo Medical University
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Chikamori Taishiro
The Department Of Medicine And Geriatrics Kochi Medical School
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Takata Jun
Department of Medicine and Geriatrics, Kochi Medical School
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Ozawa Toshio
Tokyo Metropolitan Geriatric Hospital
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Chikamori Taishiro
The Section Of Cardiology Department Of Medicine And Geriatrics Kochi Medical School
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Ozawa Toshio
Department Of Medicine And Geriatrics Kochi Medical School
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Takata Jun
The Center To Promote Creativity In Medical Education Kochi Medical School
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SASAKI MASAHIDE
Department of Clinical Laboratory Medicine, Kochi Medical School
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Chikamori Taishiro
St.george's Hospital
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Sato Takayuki
Department Of Cadiovascula Dynamics National Cardiovascular Center Research Institute
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Yamasaki Fumiyasu
Department Of Laboratory Medicine Kochi Medical School
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Doi Yoshinori
Department Of Circulation Neurology And Geriatrics Kochi Medical School Kochi University
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Sato Takayuki
Department Of Biomolecular Engineering Graduate School Of Bioscience And Biotechnology Tokyo Institu
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Sasaki Masahide
Department Of Clinical Laboratory And Department Of Medicine And Geriatrics Kochi Midical School
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Ozawa Toshio
Department of Medicine and Geriatrics, Kochi Medical School
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Doi Yoshinori
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
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