八味地黄丸のインスリン非依存型糖尿病モデルマウスに対するインスリン抵抗性改善効果

概要

論文の詳細を見る
We examined the effect of Hachimi-jio-gan (HMG), a Kampo medicine, on KK-A^y mice which were recognized as a non-insulin dependent diabetes mellitus (NIDDM) animal model. Hyperglycemia and the high level of plasma triglyceride and free fatty acid were ameliorated significantly by administration of 0.5 or 2 % HMG included in powdery diet without reduction of body weight and plasma leptin level, an obesity indicator. However, HMG did not induce the decrease of plasma glucose level in normal mice. HMG also suppressed hyperinsulinemia in KK-A^y mice. In the insulin tolerance test, the resistance to insulin in vivo was reduced by treatment with HMG. HMG is used to improve several disorders associated with diabetes in clinical. The present study suggested that HMG ameliorated hyperglycemia and hyperinsulinemia due to the reduction of insulin resistance.
1999-08-25