310 再生医療用生体由来素材の力学特性

概要

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Decellularized tissues and those recellularization are widely studied to give more durability and invisible immunogenicity to the conventional bioprostheses. We are investigating efficient processes of decellularization and recellularization of biological tissues. Our recent studies on biomechanical properties of decellularized tissues were reported. Porcine pulmonary valves and aortas were excised and treated by a newly developed method using ultrahigh pressure. They were then subjected to the histological and biomechanical studies. The results were compared with those by the decellularization using Triton X-100. The leaflet and aorta were completely cell free when new method was applied. There were no significant changes in biomechanical properties. However, the cells were still remaining inside the tissue and both of the breaking strength and elastic modulus were increased when the tissue was immersed 1% Triton X-100. Biological tissues decellularized by our new method having intact biomechanical properties may provide more durable bioprostheses.
社団法人日本機械学会の論文
2002-09-20