医療用具の放射線滅菌における滅菌線量の算出法 (I) : シグモイド型生残曲線の標的モデルに対する適合性

概要

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Estimations of the survival levels in the sigmoid shape dose-effect curves of high resistant microbes have sometimes been considered as some ploblem in the evaluation of radiation sterilization dose. Bacillus megaterium is one of high resistant microorganisms and has a broad shoulder in the curve. Multi-target and multi-hit models in the target theory, on the other hand, have been known as the models expressing the sigmoidal survival curves. The other three mathematical equations for sigmoid shape curves based on hit-target convept were also collected. Because of complicated calculations, a program which can compute the optimization of experimental data to the five equations in a single processing, was also drawn up.Experimantal results, obtained in dry state irradiation, of 27 strains of Bacillus showing sigmoidal survival curves, were computed using the program and the most suitable mathematical expression was obtained at the least residual sum of squares. Linear regression of the data of those Bacilli was also calculated and compared with that of B. subtilis and of some species of Bacilli which were known to have linear survival curves, and it seems to be some difference in the coefficient of determination and in the residual sum of squares. The computer program drawn up by us, seemed to be adequate and practical in computing the fitness of ecperimental data to the target models.
日本医療機器学会の論文
1987-08-01