小児用白血球除去フィルター PL-F1 による濃厚血小板製剤中の白血球除去能の検討

概要

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A Pall leukocyte-removal filter (PL-F1) for platelet concentrates (PCs), which has been developed for platelet transfusion for pediatric patients to handle an optimum filtration amount of 1-2 units of PCs, was evaluated to find out leukocyte-removal efficiency and recovery rate platelets. The influence of filtration on platelet functions and amount of anaphylatoxin were examined. With regard to leukocyte-removal efficiency of PL-F1,the number of residual leukocytes in PCs stored for 1,2 and 3 days was found <1.85×10^3,and their log mean removal ratet was 3.89 or higher. The platelet recovery rate after filtration of PCs stored for 1,2 and 3 days with PL-F1 was found 92.8% on average in a form of concentration recovery rate, and 85.8% when taking the amount to fill the filter into consideration. There were no significant differences in pH, morphologic score, coagulability, shape change of platelets, % HSR (% hypotonic shock response) between before and after the filtration. The amount of anaphylatoxin showed a significant decrease in C_<3a> and C_<4a>, but it showed no significant difference in C_<5a>. As for β-TG and PF-4,it showed a drop after the filtration process. Based on these results, PL-F1 was found appropriate as a filter for platelet transfusion in the pediatric field.
日本医療機器学会の論文
1995-01-01