TED-AJ03-161 COMPUTATIONAL THERMODYNAMICS OF AEROSOL TRANSPORT AND DEPOSITION IN THE HUMAN RESPIRATORY SYSTEM
スポンサーリンク
概要
- 論文の詳細を見る
The detailed knowledge of air flow structures as well as particle transport and deposition in the lung under realistic inhalation conditions is an important precursor for dosimetry-and-health-effect studies of toxic particles and for targeted drug delivery of therapeutic aerosols. Focusing on highly toxic JP-8 fuel aerosols, the 3-D airflow and fluid-particle thermodynamics, i.e., droplet motion as well as heat and mass transfer, are simulated and analyzed for laminar as well as locally turbulent low conditions (see Fig.A-1). Specifically, using a commercial finite-volume software with user-supplied programs as a solver, the Euler-Euler and Euler-Lagrange approaches for the fluid-particle thermodynamics are employed with : (i) a low-Reynolds-number k-ω model for laminar-to-turbulent airflow, (ii) scalar transport equations for temperature distribution and dispersion of JP-8 fuel vapors, and (iii) a stochastic model for random fluctuations in the droplet trajectories with evaporation. Presently, the respiratory system consists of two major segments of a simplified human cast replica : (a) the oral airways, i.e., from the mouth to the trachea (Generation 0), and (b) a four-generation (i.e., G0 to G3) upper bronchial tree model. Experimentally validated computational fluid-particle thermodynamics results show the following : (1) although the local velocity fields and vapor concentrations may be affected by the non-isothermal flow at low-level breathing (Q_<in>=15 1/min), the total and segmental deposition fractions of JP-8 fuel vapors in the upper airway are essentially not influenced by the variation of ambient temperatures (ΔT_<max>=47℃); (2) the flow rate has a significant effect on the deposition of vapors, i.e., the higher the flow rate the lower is the deposition fraction; and (3) evaporation of JP-8 fuel droplets is greatly affecting deposition in the human airway. Specifically, droplet deposition fractions due to vaporization increase with increasing ambient temperatures and decreasing inspiratory flow rates.[figure]
著者
-
Zhang Zhe
Department Of Mechanical And Aerospace Engineering North Carolina State University
-
Zhang Zhe
Department Of Chemistry Faculty Of Science Tokai University
-
Kleinstreuer Clement
Department Of Mechanical And Aerospace Engineering
-
Kleinstreuer Clement
Department Of Mechanical And Aerospace Engineering North Carolina State University
関連論文
- TED-AJ03-161 COMPUTATIONAL THERMODYNAMICS OF AEROSOL TRANSPORT AND DEPOSITION IN THE HUMAN RESPIRATORY SYSTEM
- Gas Chromatographic Determination of Trace Amounts of Amines Using Sanarumin Adsorbent
- Effects of SiO_2 Particles on Deformation of Mechanically Milled Water-Atomized SUS304L Powder Compacts
- Computational Thermodynamics Analysis of Vaporizing Fuel Droplets in the Human Upper Airways(Emerging Fields in Thermal Engineering)