腎に於ける抗原抗体反応並びに類似現象に関する電子顕微鏡学的研究 : 第3編 自己腎乳剤による実験
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Continuing the investigation of the previous report, the author reported on the electron microscopical changes in the kidney caused by the active immunization of auto-renal extract, and these investigation is a part of the studies on the antigen-antibody reaction in the kidney. On the experimental method, normal rabbits were immunized intraperitoneally with auto-renal suspension prepared by the unilateral nephrectomy. A total of ten times immune injections was executed once weekly, and one or six weeks after the last injection, these rabbits were sacrificed and the electron microscopical changes of the remaining kidney were observed. In seven of these ten rabbits, remarkable glomerular changes were observed as follows: 1) Major findings were degenerative or proliferative changes of the epithelial cells of glomerulus and Bowan's capsels, namely mitochondrial swelling, enlargement of endoplasmic reticulum and deposition of homogenous granules within cytoplasma of the epithelial cells. 2) Glomerular tufts showed remarkable dilatation and basement membranes were slight swelling or thining with decrease of density, and on Bowman's capsels, remarkable fibrous thickening of the basement membranes were observed. 3) Rarely, mesangial cells showed swelling with filamentous structural matrix. 4) But no significant changes were observed on the glomerular endothelial cells except slight swell ing of the endothelial layers. On the author's three experimental renal shocks caused by different antigen or antibodies, three different types of glomerulitis were observed, namely mesangial glomerulitis by anti-kidney serum, endothelial glomerulitis by anti-thymic serum and epithelial glomerulitis by auto-renal extract. Similar glomerular changes to these glomerulitis are observed on the other experiments by Hamamoto and his co-workers using various antigens or antibodies and autopsy cases of various diseases too, for example, mesangial glomerulitis are found in cases of acute glomerulonephritis and Schonlein-Henoch purpura, endothelial glomerulitis are in cases of thrombotic thrombocytopenic purpura and epithelial glomerulitis are in pyelonephritis and tuberculosis of the kidney. The results of the author's three experiments suggest that these different types of glomerulitis occur by the kinds of sites on which antigen-antibody reactions are caused.
- 日本アレルギー学会の論文
- 1966-03-30
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