腎に於ける抗原抗体反応並びに類似現象に関する電子顕微鏡学的研究 : 第2編抗胸腺血清による実験

概要

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1) Renal anaphylactic shock was induced by single injection of the anti-rabbit-thymus guinea pig serum. In one group of the male rabbits the antiserum was injected into the left renal artery, and in the other male or pregnant rabbits the injection was carried out similarly into the marginal ear vein, and these glomerular changes of the rabbits kidneys were investigated using electron and light microscopy. 2) In these glomerular changes no significant differences were observed between male rabbits and pregnant rabbits more over two groups. 3) By light microscopy, remarkable swelling degeneration and necrosis of the endothelial cells, epithelial cells, partial in mesangial cells of glomerular tuft and tubular epithels, and by electron microscopy various findings were observed, namely mitochondrial swelling or pyknosis in light and disorganization of cytoplasmic organelles in severe glomerular lesion, and usual nucleus formed irregular. 4) These features are similar nature to those in the examinations of the effect upon the liver or spleen by same antibody or anti-histone serum, and these glomerular changes like the human glomerulitis in autopsied cases of malignant tumor or receiving blood transfusion in large quantity.
日本アレルギー学会の論文
1965-03-30