4.リウマチ様関節炎の関節液中のキニン系酵素と細胞内酵素の起源(第2回プラズマキニン研究会)

概要

論文の詳細を見る
Recent claims that kinin-forming and kinin-destroying enzymes are located in leucocytes(Eisen 1966; Greenbaum & Kim 1967; Cline & Melmon, 1967)have raised the possibility that the role kinins might play in inflammation depends mainly on the participation of leucocytes. In the present experiments we have determined the concentrations of kinin-forming and kinin-destroyting enzymes as well as lysosomal and cytoplasmic enzymes and protein in samples of synovial fluid collected from patients with rheumatiod arthritis and related diseases. The concentrations of acid phosphatase, β-glucuronidase, lactic dehydrogenase and glutamic oxalacetic transaminase were higher in non-centrifuged cell containing synovial fluid than in centrifuged cellfree samples. Furter the concentrations of the enzymes in the cell free fluid were higer than those in plasma. These findings suggest that the enzymes are derived from the cells of the synovial fluid(leucocytes and synovial lining cells)and not from the plasma. In contrast the kinin-forming and kinin-destroying enzymes and protein in synovial fluid are derived from plasma since their concentrations in cell containing synovial fluid were equal to or lower than those in wither cell free fluid or in plasma. This view was strengthened by the finding that after centrifugation of synovial fluid the pellet contained large amounts of the intracellular enzymes but only traces of the kinin-enzymes and protein. In addition when we compared kinin-forming and kinin destroying activities of synovial fluid with those of plasma they were qualitatively similar. It is concluded that the intracelluar enzymes of the synovial fluid are derived mainly from the synovium and the leucocytes whereas the kinin enzymes originate from the plasma.
日本アレルギー学会の論文
1968-04-30

4.リウマチ様関節炎の関節液中のキニン系酵素と細胞内酵素の起源(第2回プラズマキニン研究会)

スポンサーリンク

概要

著者

関連論文

スポンサーリンク