気管支喘息の研究 : 第1報. Allergy Centre 2年半における気管支喘息の臨床集計成績

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In 213 cases of bronchial asthma treated and observed in our Allergy Centre during the period from July 15, 1964 to January 14, 1967, the results of clinical studies are as follows:- 1) As to the sexual distinction, male/female ratio of the adult patients (127 cases) with bronchial asthma is 1.59, and that of the pediatric (86 cases) is 2.58. 2) 70.9% of the adult patients and 53.5% of the pediatric have the hereditary diathesis of allergic diseases. 3) According to the complaint of the patients, we investigated what is thought as inductive to asthmatic attacks. It is considered that house dust, smoke, insecticides, paints, woods, etc. have inductive relation to asthmatic attacks; and likewise do egg, milk, chocolate, chicken; yam, taro, spinach, sweet glutinous 'sake', bambooshoot, egg-apple, buckwheat; curry, mustard, etc. The attack frequency of asthma is heightened in October, September, November, March, April, for the year; and from midnight to dawn for the day. Weather before rain, menstruation, overworking, overeating, want of sleep, exitement, irritation, strain, physical exercise or laugh also proved to have some relation to induce asthmatic attacks. 4) The intracutaneous test by inhalatory allergen extracts was tried to examine the sensitivity in each subject. The frequency order of positive reaction was as follows: house dust (62.3%, the highest of all), aspergillus mould, common ragweed pollen, cat's tail pollen (typha angustata), old mat, silk, cottonwool, buckwheat husks, and so on. As to the intracutaneous test by food allergen, positive reaction in children for white of egg and yolk was conspicuous. In 31.5% of all patients, positive reaction to intracutaneous test using these substances coincided with more than one cause stated by subjects. And in 22.0%, positive reaction was proved to some of these substances although subjects did not state any causes of astmatic attacks. Especially in the test by house dust allergen, positive reaction was approved in 69.3% who affirmed the relation to these substances, and as well in 57.1% who denied the relation. 5) From the results of routine clinical examinations, following points are noticed:- a) On summarizing the results of various kinds of examintion, the diagnosis of hepatitis was given in 6 cases with bronchial asthma, and the disorder of hepatic function did not run parallel to the seriousness of asthma. b) In 21 of 60 cases examined by means of electrocardiography, some abnormal curves were noticed. c) Some increasing tendency of WBC was observed in cases of asthmatic attacks, and considered to be related with the infection. Eosinophilia was also noticed in 78.8% of 193 cases during the whole period of observation, and ti seemed to become remarkable simultaneously with astmatic attacks. d) The hypofunction of adrenal cortex was seen in 2 of 12 cases with bronchial asthma, but the number of cases examined was too small to prove the definite tendencies of adrenal function. e) Serum total protain, A/G ratio and protein fraction were normal in large majority of the subjects with bronchial asthma. Only in one case, remarkable hypo-γ-globulin fraction was noticed, and it seems that the interpretation of such abnormality would be a task to be done in the future.
1967-06-30

著者

中村晋
国立静岡病院Allergy Centre

気管支喘息の研究 : 第1報. Allergy Centre 2年半における気管支喘息の臨床集計成績

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