牛フィブリノーゲンによる抗原抗体反応に関する研究 : 第1報肝における活動性アナフィラキシー時の病理組織学的変化について

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An experiment was carried out to clarify the pathogenetic mechanism of the allergicchepatitis induced by the active anaphylaxis in rabbits sensitized with the bovine fibrinogen. The rabbits were sensitized with the bovine fibrinogen intravenously in 6 times and then 7 days after sensitizing injection, the provocative injection was made into the portal vein or the marginal ear vein of the rabbits. Rabbits were sacrificed by the total bleeding from 24 to 48 hours after the provocative injec tion, and the histological changes of the liver caused by this active anaphylaxis were investigated. Major histological changes were as follows: 1) various degree of diffuse degeneration of hepatic cells, 2) parenchymal necrotic foci, 3) cell infiltration in the sinusoids and in the portal area, 4) dilatation of central vein and sinusoid, 5) thromobosis, 6) dilatation of interlobular veins, 7) edema of connective tissues in portal area, 8) dissecting phlebitis of interlobuler veins. No significant changes were found in the control animals. Changes of the some exminations results were as follows: 1) increase of red blood cells, 2) prolongation of blood coagulation time, 3) increase of total serum protein and γ-globulin. These changes were caused by antigen-antibody reaction of bovine fibrinogen which was heterogenous antigen and by many times of sensitized injection wth it. From the results of the author's experiment, it might be said that the hepatic changes were caused by the intra- and extra-vescular antigen-antibody reaction.
日本アレルギー学会の論文
1967-03-30

牛フィブリノーゲンによる抗原抗体反応に関する研究 : 第1報肝における活動性アナフィラキシー時の病理組織学的変化について

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牛フィブリノーゲンによる抗原抗体反応に関する研究 : 第1報 肝における活動性アナフィラキシー時の病理組織学的変化について

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牛フィブリノーゲンによる抗原抗体反応に関する研究 : 第1報肝における活動性アナフィラキシー時の病理組織学的変化について