ラットの大網における脾組織片移植にさいしての局所組織反応の研究

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In connection with immunological processes of homograft rejection, a comparative study was performed on hetero-, homo- and autotransplantation in the rat. Hetero (rabbit)-, homo- and autogenous splenic tissues were transplanted into th omentum of rats. Tissue changes taking place around the graft as well as in itself were examined histo-pathologically at intervals. The following results have been obtained. 1) The graft tissues were organized completey in thirty days with newly formed granulation tissue in hetero- and homotransplantation, whereas some lymphocytes and reticular cells were still slive at this time without marked proliferation of granulation tissue in autotransplantation. The necrotizing processes of the graft tissue and it organization resulting fibrosis were most profound in hetero transplantation. 2) Basophilic globular corpuscles originated in nuclear substance morphologically resembling hematoxylin bodies were observed in graft tissues. The precise causal genesis of development of the corpuscles obtained here, however, still remained indefinite in the present study. 3) Proliferation of the granulation tissue surrounding the graft was most evident in heterotransplantation, moderate in homotransplantation, and scarcely recognized inautotransplantation. 4) In the serum of the rat with hetero- and homotransplantation, antibody against donor's red cells was found by the hemagglutination test, respectively. From these findings, it has been concluded that the proliferation of granulation tissue surrounding the graft may be a focal immune reaction at the omentum tissue attempting the rejection of transplanted tissue.
日本アレルギー学会の論文
1966-10-25

ラットの大網における脾組織片移植にさいしての局所組織反応の研究

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