マウスのアナフィラキシー反応におけるHistamineおよびSerotoninの役割

概要

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Schultz-Dale reaction of the mouse uterus was not inhibited by the presence of antiserotonin substances, LSD, BOL or UML (Deseril), provided that they are used in concentrations which do not affect the contractile ability of the uterine muscle. The contents of serotonin in the skin and uterus underwent no changes after anaphylactic shock, whereas skin histamine was reduced by about 30 per cent. Serotonin-sensitive mouse jejenumfailed to demonstrate in vitro anaphylactic release of serotonin either from the skin or uterus. During in vitro anaphylaxis of the mouse uterus a substance inducing a slow-developing contraction of guinea-pig ileum was released into the medium containing an antihistamine, Neoantergan. Significant protection was afforded against anaphylactic shock by the prechallenge treatment of repeated injections of a histamine liberator, sinomenine, which depleted about 50 per cent of the skin histamine, and also by repeated injections of a large dose of histamine which desensitizes some reactions to this amine. Neoantergan and UML, and also a combined use of the both were of no effect. These results suggest an important role of histamine release in the mouse anaphylaxis, while the role of serotonin is uncertain.
1965-05-30