悪性腫瘍の抗原性に関する研究 : 主としてGel内沈降反応Immunoelectrophoresisを応用せる抗原性の検討

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As an approach to the immunological studies of cancer, changes of cancer antigenicity were carried out mainly by means of immunochemical analysis like as gel diffusion technique and immunoelectrophoresis, which were specific antigen-antibody reaction. Thereafter the following conclusions were obtained. 1) The results of biochemical analysis of serum protein fractions by Tisselius or some other methods did not show to be any specific for cancer, but the immuno-chemical analysis can show pretty significant factors of the specific antigenicity. 2) In serum or ascites of transplantable animal cancer as Ehrlich ascites tumor in mice and Yoshida sarcoma in rats, specific antigen ingredients of cancer could be found, although not be proved in normal animals. So these factors were electrophoretically in α_1- and α_2- glubulin region. 3) In serum and ascites in cancer patients, electrophoretic specifity were shown in α-globulin region, especially in α_1-globulin. 4) Those specipitation pattern in α-globulin region showed a little difference by cases and antiserum used. 5) Degrees of antigenicity of cancer serum have some relation to progress of cancer invasion and primary genetic tissue, therefore general protein metabolism strongly infiuences it and results quantitative difference. 6) In every tissue protein, specific antigens as organ specificity as well as common antigens, were demonstrated. 7) The alteration of antigenic structure of cells due to malignisation shows that the antigenic structure becomes more simple because of the disappearance of some normal antigens from the cancer cells(loss), on the other hand it becomes more complex in connection with the appearing of some new antigens in cancer cells (gain). It seems that this changes differences by the case and the stadium, of cancer. 8) Cancer specific antigens identified by gel diffusion method are very weak and these specific factors are soluble in 1/3 (NH_4)_2SO_4 saturated solution at 4 C, pH 7.0, but not in 1/2 (NH_4)_2SO_4 saturated solution at same temperature and pH, and are electrophoretic to positive pole. 9) As far as stomach cancer is concerned, cancer specific antigens are common with each stomach cancer beyond the individual speciflcity.
日本アレルギー学会の論文
1965-03-30

悪性腫瘍の抗原性に関する研究 : 主としてGel内沈降反応Immunoelectrophoresisを応用せる抗原性の検討

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