腫瘍異種移植に関する実験的研究 : 主としてImmunological tolerance応用の場合

概要

論文の詳細を見る
From the hypothesis on immunological tolerance for heterotransplantation of tumors, the authors performed some experimental studies using YOSHIDA ascites sarcoma as rat tumor and EHRLICH ascites type carcinoma as mouse tumor. Tumor cell homogenates, tumor cell suspensions and spleen cell suspensions were injected intraperitoneally as antigens for initial exposures to each group of new born mice and rats. Thus treated animals were fed for 4 weeks, and then experimental tumors were heterologously transplanted and its morphorogical changes were observed thereafter microscopically. In groups, treated with tumor cell suspensions and tumor homogenates, immunological tolerance were not established and transplanted tumor cells were regressed in early stages ; In contrast, in groups treated with spleen cell suspensions, transplanted tumor cells were recognized as take and immunological tolerance seemed to be established.
日本アレルギー学会の論文
1963-07-30