副腎皮質HormoneのHistamine遊離抑制作用

概要

論文の詳細を見る
Hydrocortisone, prednisolone, and dexamethasone were studied for their action on the histamine release in the skin of albino rat. These glucocorticoids evidently inhibited the reduction of skin histamine induced by dextran in their optimal doses, individually not affecting the histamine content, when injected intramuscularly in divided doses 24 hours and I hour prior to intraperitoneal administration of dextran. Their inhibitory effect reached the maximum (approximately 70 percent inhibition) with the dose 10 mg/kg of hydrocortisone acetate, 5 mg/kg of prednisolone acetate, and 1 mg/kg of dexamethasone respectively, whereas at the dosages larger than the above mentioned the inhibitory effect rather decreased. Relative potency of these glucocorticoids, in terms of doses producing the maximum effect, was proportional to their anti-inflammatory effect.
日本アレルギー学会の論文
1963-11-30