担癌宿主の抵抗性に関する研究 : 第2編破傷風抗毒素の産出について

概要

論文の詳細を見る
In order to ascertain a possibility that a capacity of antibody production against a certain bacterial antigen might share with the tumor-specefic resistance, antitoxin response in tumorbearing hosts was studied by means of active immunization with tetanus toxoid. The primary response in 28 cancer patients was significantly impaired with that in 23 normal subjects. However, the secondary response was equally elicited with toxoid in cancer patients as in normal subjects. Growth of tumor autografts was observed among patients whose antitoxin level was relatively high as well as among patients with little or no antitoxin. Therefore, the present study reveales that the defensive capacity of a host against cancer cannot be evaluated with such an indicator as tetanus antitoxin. It seems more likely from available evidences that the immune response of tumor-bearing individuals is characteristic of lowered delayed-type reaction rather than impaired production of humoral antibodies.
日本アレルギー学会の論文
1963-11-30