担癌宿主の抵抗性に関する研究 : 第1編 血清ファージ中和能について
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概要
- 論文の詳細を見る
In an attempt to evaluate the natural defense mechanisms against cancer in humans, the bacteriophage neutralizing activity of sera was assayed in 53 patients with malignant neoplasms, and the values were compared with those in 25 normal healthy subjects, in 30 patients with tuberculosis and 25 patients with miscellaneous diseases. The cancer sera showed the same distribution and range of the activities as the normal and other pathological sera. The neutralizing activity of a serum against T3 phage was always higher than that against T2, but the two values were not always proportional. There was no correlation between the phage neutralizing activiny and the positive reaction to C-reactive protein antiserum. A limited number of cancer sera showed a tendency to negative correlation between the phage neutralizing activity and amounts of serum γ-globulin, but this was not conclusive. The administration of a large dose of Mitomycin-C during a few days for the treatment of cancer resulted in a remarkable fall in the neutraliziing activity, but a medium dose of the drug given once a week hardly influenced the activity. No parallelism could not be established between the phage neutralizing activity and the zymosan units of properdin. The phage neutralization technique was originally described as a method for assaying serum properdin. Recently, evidences have increased to indicate that the properdin is a family of natural antibodies present in sera which cross-react widely with various polysaccharides of bacterial and animal origin and also with several kinds of viruses, including bacterisphages. Therefore, the present study indicates that one of these natural antibodies remains even in the advanced stage of malignant diseases without defensive effect against tumors.
- 日本アレルギー学会の論文
- 1963-11-30