栓球による血管内性抗原抗体反応に関する研究 : 第3編逆アナフィラキシー時の脾臓の組織学的変化

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Continuing the investigation of report I and II, the author carried out an experiment of the intravascular antigen-antibody reaction of thrombocyte. This paper was described macroscopical and histological changes of the spleen in rabbit which were injected with the anti-rabbit thrombocyte guinea pig serum into the splenic artery and were autopsied periodically from twenty-four hours to fourteen days after the provocative injection. In the gross finding of the spleen, hemorrhagic infanction were frequently observed in the 24th and 48th hour groups, but in the 7th and 14th day groups no significant changes were found macroscopically. In the histological observation, the remarkable changes were as follows: atroyhy of follicle and proliferation of endothelial cells of arteria centralis in the white pulp. In the red puly, necroses with hemorrhage, congestion and dilatation of sinusoids, swelling of the sinus endothelial cells, perifollicular inflammation, thrombophagocytosis, hemosiderosis, appearance of megacaryocytes in the sinusoids, proliferation of reticular cells and edema of the trabeculae.
日本アレルギー学会の論文
1962-06-30