γ-Globulinによる血管内性抗原抗体反応に関する研究 : 第1編 活動性アナフィラキシー時の肺及び心の変化について : 附, 末梢血及び血清蛋白の変動

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概要

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• In relation to the systemic necrotizing angitis due to the "collagen diesase", a series of experiments were carried out to clarify the pathogenetic mechanism of the allergic angitis induced by the active anaphylaxis in rabbit sensitized with the human and bovine serum gamma globulin. Based upon the Hamamoto's theory of "Intravascular Antigen-Antibody Reaction", these heterologous serum gamma globulins were injected intravenously through the marginal ear veins into rabbits whose serum titer against these serum gamma globulins were sufficiently high. Rabbits were sacrificed from one day to fifteen days after the provocative injection, and then the pathohistological changes of the lung and the heart were examined. At the same time, in the course of each experiment, hematological changes of the peripheral blood and electrophoretic changes of the serum protein were observed. Major pathohistological changes were those of vessels in the lung. The changes were as follows; (1) proliferation and degeneration of the endothelial cells of arteries, occasionally showing some granulomatous formation, and intense edema in the subendothelial area, (2) productive endarteritis mainly in the muscular arteries, sometimes accompanied by the formation of granulomatous plugs. (3) stricture or obstruction of the arteries and thrombi in the arteries as the results of the endothelial changes described above, (4) necrotizing arteritis of the muscular arteries chiefly attributable to fibrinoid necrosis of tunica media. Occasionally dramatic necrotizing panarteritis including the necrosis of both innercoat and tunica media. (5) fibrinoid necrosis of arteriolar walls, (6) perivascular infiltration of pseudo-eosinophile leucocytes, (7) productive endophlebbitis in small veins. These arterial changes were most remarkable in the period between two days and five days after the provocative injection. In addition to the vascular changes mentioned above, the septal inflammation(interalveolitis) without any inflammation nor exsudation in the alveolar cavities was observed in the lung and the nodular proliferation of alveolar epithelial cells remained prominent fifteen days after the provocative injection. The histological changes in the heart were as follows; (1) slight arterial changes in comparison with those in the lung, (2) foci of vacuolar and waxy degeneration and of waxy necrosis in the myocardium, (3) stasis and small hemorrhage in the myocardium, (4) slight fibrinoid swelling of the endocardium. Then, the hematologic and electrophoretic changes were as follows; (1) intense anemia, (2) remarkable fluctuation in the number of circulating leucocytes, showing leucocytosis five days after the provocative injection, (3) dramatic changes of the total serum protein, (4) hypergammaglobulinemia from two hours to about two days after the provocative injection, and hyperalbuminemia with hyperproteinemia following five days after the provocative injection. These pathohistological changes, especially the arterial changes in the lung, resembled the pattern of "collagen disease" to which belong systemic lupus erythematosus or periarteritis (or polyarteritis) where the typical pathohistological changes of arteries are found, These observation indicated that the pathogenesis of the diffuse systemic necrotizing angitis of collagen disease may be of "allergic" mechanism.

• 日本アレルギー学会の論文
• 1961-09-30

著者

• 津田 考憲

  大阪医科大学病理学教室

• 津田 孝憲

  大阪医科大学病理学教室

関連論文

• γ-Globulinによる血管内性抗原抗体反応に関する研究 : 第3編 活動性アナフィラキシー時の脾変化について
• γ-Globulinによる血管内性抗原抗体反応に関する研究 : 第2編 腎における活動性アナフィラキシー時の変化について
• γ-Globulinによる血管内性抗原抗体反応に関する研究 : 第1編 活動性アナフィラキシー時の肺及び心の変化について : 附, 末梢血及び血清蛋白の変動
• 37. γ-Glcbulin における血管内性抗原抗体反応 第1編 : 活動性アナフィラキシー時の病理組織学的変化(第10回日本アレルギー学会総会一般演題)

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