腸内細菌叢とくに大腸菌属による生体の感作とその意義に関する研究 : 第11報大腸菌感作ウサギの腸管に対する赤痢菌および大腸菌の起病性

概要

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To elucidate what role the cross allergic reaction plays in the pathogenesis of dysentery and enteritis on the basis of sensitization by Escherichia coli, rabbits rectally sensitized with E. coli 0-13 and untreated were inoculated by De and Chatterije's method in their isolated loops of intestine with E. coli 0-13 or Shigella flexneri 2b, which has an antigen in common with the former, and the development of enteritis was observed both macroscopically and microscopically. Seven out of 11 E. coli-sensitized rabbits developed enteritis in the small and large intestine after the inoculation of E. coli. After the inoculation of Sh. flex., enteritis developed in the large and small intestine in 7 cases out of 13 sensitized animals. On the other hand, the inoculation of E. coli induced enteritis in the small intestine of 3 and in the large intestine of 4 of 13 control rabbits, and that of Sh. fiex. in the small intestine of 3 and in the large intestine of 1 of 12 controls. Enteritis induced by E. coli and Sh. flex. resembled each other both macroscopically and microscopically. Histologically necrotic fibrinous hemorrhagic enteritis was observed, and the finding is similar to that in human dysentery. These results seem to clarify the relationship between E. coli sensitization and development of dysentery and enteritis, indicating the participation of allergic factor in their pathogenesis.
一般社団法人日本アレルギー学会の論文
1961-05-30