腸内細菌叢とくに大腸菌属による生体の感作とその意義に関する研究 : 第10報 大腸菌抗原による経直腸感作の成立

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概要

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• For the purpose of clarifying the process of natural sensitization by intestinal flora, somatic antigen of E. coli were rectally given to guinea pigs and rabbits. Agglutination reaction, Arthus phenomenon and Schultz-Dale reaction were also tested for demonstrating the rectal sensitization. Agglutination test with E. Coli was conspicuously observed to be positive in all of 28 rectally sensitized adult rabdits; the titer was 10-160 X at the pre-sentsitization, but it showed 80-5, 120 X after the sensitization. The rise of the agglutinin titer was also seen in 9 out of 23 young rabbits sensitized in the same procedure; after the sensitization the agglutinin titer was elevated to 20 X in 3 cases. to 40 X in 1, to 160 X in 2, 320 X in 1, to 640 X in 1 and to 1280 X in 1, though the initial titer of them were only 10 X. Furthermore, the facts were observed in some of rectally sensitized guinea pigs. In the rabbits sensitized rectally and orally, the higher hemagglutination titer was demonstrated in the former with smaller doses, only with 1/3-1/10 of those in the latter. Skin test was performed on rectally sensitized rabbits and guinea pigs, and some of them were proved to be positive in Arthus phenomenon. Schultz-Dale reaction was also positive in some of rectally sensitized guinea pigs. In this case the difficulty of the desensitization seemed to be characteristic. To summarize, when E. coil antigen was given to the guinea pigs and rabbits, agglutinin titer being elevated, positive Arthus phenomenon and Schultz-Dale reaction were demonstrated. These facts suggest that the intestinal sensitization by bacterial antigen was considered to be an important route in natural sensitization by E. coli.

• 一般社団法人日本アレルギー学会の論文
• 1961-04-30

著者

• 深井 登起子

  群馬大学小児科学教室

関連論文

• 腸内細菌叢とくに大腸菌属による生体の感作とその意義に関する研究 : 第11報 大腸菌感作ウサギの腸管に対する赤痢菌および大腸菌の起病性
• 腸内細菌叢とくに大腸菌属による生体の感作とその意義に関する研究 : 第10報 大腸菌抗原による経直腸感作の成立

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