炎症に関与する化学的因子の研究 : 第2篇炎症巣に於けるヒスタミンに関する研究

概要

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In order to study on the role of histamine in the development of inflammation, changes of the skin histamine contents in response to antigenic stimulus in the rabbit sensitized with egg albumin were observed. Following the McIntire's method, histamine was extracted from the skin samples and quantitatively determined by the bioassay technique using atropinized guinea pig ileum. The histamine contents of the lateral abdominal skin of the normal rabbit were found 0.5-2.0 μg. per gram of skin tissue. This value was not significantly changed by sensitization. Significant changes were not observed in the skin histamine contents in the early stage of Arthus phenomenon. This fact suggests that the skin histamine does not play and important role in the development of inflammation.
一般社団法人日本アレルギー学会の論文
1961-04-30